“…Notably, 7% of the 96 online purchasers of tramadol experienced serious adverse events (life-threatening seizures) versus no seizures in the 349 who purchased tramadol with a prescription at a local pharmacy. Other examples of serious adverse reactions in patients who took self-prescribed medications from the Internet include lithium toxicity from a dietary supplement (Pauzé and Brooks, 2007), severe hypotension from high-dose niacin by a patient with schizophrenia (Mularski et al, 2006), and panic attacks from selegiline and phenylethylamine by a patient with depression (McKean et al, 2015).…”