The Perinatal Depression Treatment Cascade

Cox, Elizabeth; Sowa, Nathaniel A.; Meltzer‐Brody, Samantha; Gaynes, Bradley N.

doi:10.4088/jcp.15r10174

Cited by 295 publications

(125 citation statements)

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“…Prominent consequences of PPD include maternal suicide, infanticide, and reduced maternal sensitivity, which can adversely affect emotional regulation and infant attachment leading to adverse neurodevelopmental outcomes for the child 1 – 7 . However, despite the potentially profound effects on mother and child, PPD is often under-diagnosed, understudied, and inadequately treated 8 .…”

Section: Introductionmentioning

confidence: 99%

PPD ACT: an app-based genetic study of postpartum depression

et al. 2018

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Postpartum depression (PPD) is one of the most frequent complications of childbirth and particularly is suited to genetic investigation as it is more homogenous than major depression outside of the perinatal period. We developed an iOS app (PPD ACT) to recruit, consent, screen, and enable DNA collection from women with a lifetime history of PPD to sufficiently power genome-wide association studies. In 1 year, we recruited 7344 women with a history of PPD and have biobanked 2946 DNA samples from the US. This sample of PPD cases was notably severely affected and within 2 years of their worst episode of PPD. Clinical validation was performed within a hospital setting on a subset of participants and recall validity assessed 6–9 months after initial assessment to ensure reliability of screening tools. Here we detail the creation of the PPD ACT mobile app including design, ethical, security, and deployment considerations. We emphasize the importance of multidisciplinary collaboration to correctly implement such a research project. Additionally, we describe our ability to customize the PPD ACT platform to deploy internationally in order to collect a global sample of women with PPD.

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Section: Introductionmentioning

confidence: 99%

PPD ACT: an app-based genetic study of postpartum depression

et al. 2018

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“…8 Studies have suggested that only 3.2% of women with PPD achieve remission with current treatments. 9 Preclinical and clinical studies have shown that neuroactive steroids might have an important role in the pathophysiology of PPD. 7 Specifically, the inability of the GABA system to adapt to changes in neuroactive steroid levels during the peripartum period may mediate the onset of PPD symptoms.…”

Section: Innovation And/or Advantagesmentioning

confidence: 99%

Case-based learning: postnatal depression

2020

Pharmaceutical Journal

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This briefing reflects the evidence available at the time of writing and a limited literature search. It is not intended to be a definitive statement on the safety, efficacy or effectiveness of the health technology covered and should not be used for commercial purposes or commissioning without additional information. A version of the briefing was sent to the company for a factual accuracy check. The company was available to comment.

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“…[3][4][5] Only 15.8% of women with PPD receive treatment, 6.3% receive adequate treatment and 3.2% achieve remission. 6 It is within this context that Posmontier et al aim to enhance access to evidence-based care for PPD by using a more convenient delivery system (eg, telephone) and providing treatment by a trusted, less stigmatising healthcare provider (eg, nurse-midwife).…”

Section: Contextmentioning

confidence: 99%