The perinatal origins of major reproductive disorders in the adolescent: Research avenues

Brosens, Ivo; Curcić, A; Vejnović, T; Gargett, Caroline E.; Brosens, Jan J.; Benagiano, Giuseppe

doi:10.1016/j.placenta.2015.01.003

Cited by 29 publications

(27 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the functional significance of progesterone withdrawal in the neonatal period is not fully understood, we have provided persuasive evidence that NUB should not be ignored, but actually may represent an important biomarker for reproductive events that can occur during adolescence 3–8 .…”

mentioning

confidence: 88%

See 1 more Smart Citation

Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife

Puttemans

Benagiano

Gargett

et al. 2016

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

Neonatal uterine bleeding (NUB) occurs in approximately 5% of newborns, and is generally considered to be of little clinical significance. However, the real clinical importance of this condition and its long-term implications remain to be determined. The reason why NUB is rare despite high circulating levels of progesterone can be attributed to a progesterone resistance present in a majority of neonates. Recent work indicates that NUB represents a significant biomarker for events that can occur later-on during adolescence. Indeed, clinical studies have shown that “neonatal menstruation” constitutes a sign of fetal distress during late pregnancy, reflecting a stage of endometrium development that may subsequently have an impact on the reproductive life of the adolescent and the young adult. Via retrograde flow, NUB can cause endometrial stem/progenitor cells to arrive into the pelvic cavity and survive there, dormant underneath the peritoneal surface, until menarche activates them. Indeed, there is both clinical and epidemiological evidence of a link between NUB and adolescent endometriosis. In addition, if progesterone resistance persists till the onset of menarche, in case of an early teen pregnancy, it can result in a disorder of deep placentation. Therefore, we propose that NUB should be carefully recorded so that prospective studies can examine its links with reproductive disorders in adolescence and beyond.

show abstract

mentioning

confidence: 88%

“…It will be her first and last menstrual period for another decade or so ” 2 . Despite this neglect, NUB has recently been the subject of re-evaluation 3–8 . Intriguingly, neonatal bleeding has been extensively described in the European literature for almost two centuries 9 and, more than a century ago, it was labelled as “ neonatal menstruation ” 10 .…”

mentioning

confidence: 99%

Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife

Puttemans

Benagiano

Gargett

et al. 2016

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

show abstract

“…[5][6][7][8][9][10] This hypothesis is based on a series of intriguing observations. Like menstruation, NUB is triggered by the rapid fall in circulating progesterone levels in the first few days after birth.…”

Section: Origins Of Early-onset Endometriosismentioning

confidence: 99%

Origins and Progression of Adolescent Endometriosis

et al. 2016

View full text Add to dashboard Cite

Accumulating evidence indicates that adolescent endometriosis is common and often severe. Here we explore the possibility that seeding of naive endometrial progenitor cells into the pelvic cavity early in life, that is, at the time of neonatal uterine bleeding or soon after the menarche, results in more florid and progressive disease, characterized by highly angiogenic implants, recurrent ectopic bleeding, and endometrioma formation. We discuss the potential intergenerational risk factors associated with earlyonset endometriosis and explore the molecular drivers of disease progression. Taken together, the available data suggest that an increased focus on early-life events may help to identify young women at risk of severe, progressive endometriosis.

show abstract

“…It can be speculated that the type of progesterone resistance present in the endometrium at birth is likely to persist till the onset of puberty when endogenous estrogens begin to stimulate endometrial cells [26,27]. While full progesterone response with 'neonatal menstruation' has been linked to pelvic endometriosis in premenarche and adolescence [26,27], a persisting degree of progesterone resistance of the endometrium after menarche can be linked to defective deep placentation and major obstetrical disorders, including preeclampsia, fetal growth restriction and preterm birth [28,29].…”

Section: Neonatal Progesterone Response Resistancementioning

confidence: 99%

Menstrual preconditioning for the prevention of major obstetrical syndromes in polycystic ovary syndrome

Brosens

Benagiano

2015

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

The presence of multiple ovarian cysts, anovulation, and endometrial progesterone resistance in the neonate seems remarkably similar to ovarian and endometrial features of the polycystic ovary syndrome (PCOS) of adolescent and adult women. In fact, in the absence of cyclic menstruations after menarche, the neonatal progesterone resistance is likely to persist and adversely affect young women with PCOS at the time of pregnancy after induction of ovulation, because any persisting defect in progesterone response can interfere with the process of decidualization and trophoblast invasion. The primigravid woman with PCOS therefore is likely to be at risk of defective deep placentation as manifested by the increased risk of major obstetric syndromes. A recent, large epidemiologic study has demonstrated that the risk of preeclampsia and preterm delivery is elevated in the 13- to 15-year old group, although it does not persist in the 16- to 17-year old group. It is proposed therefore that induction of ovulation in the infertile nulligravid woman with PCOS should be preceded by a period of progesterone withdrawal bleedings to achieve full endometrial progesterone response by the time of pregnancy. The cyclic administration of clomiphene citrate for a period to be determined by vascular response may be an appropriate tool to reduce the risk of major obstetric syndromes by menstrual preconditioning.

show abstract

The perinatal origins of major reproductive disorders in the adolescent: Research avenues

Cited by 29 publications

References 28 publications

Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife

Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife

Origins and Progression of Adolescent Endometriosis

Menstrual preconditioning for the prevention of major obstetrical syndromes in polycystic ovary syndrome

Contact Info

Product

Resources

About