The perioperative granulocyte/lymphocyte ratio is a clinically relevant marker of surgical stress in patients with colorectal cancer

Shimazaki, Jun; Satani, Tetsuro; Nakachi, Takeshi; Watanabe, Yoshinori; Tabuchi, Takafumi

doi:10.1016/j.cyto.2010.10.004

Cited by 28 publications

(22 citation statements)

References 36 publications

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“…Therefore, a high pre-operative G/L ratio may be a reliable biomarker to identify patients with poor prognosis after resection of gastric cancer or colorectal cancer [36,37]. Additionally, during stress, we found a significant positive correlation between the G/L ratio and serum IL-6 level, which is in line with a previous study [9]. …”

Section: Discussionsupporting

confidence: 81%

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In Patients with Colorectal Cancer, Preoperative Serum Interleukin-6 Level and Granulocyte/Lymphocyte Ratio Are Clinically Relevant Biomarkers of Long-Term Cancer Progression

Shimazaki¹,

Goto²,

Nishida³

et al. 2013

Oncology

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Objective: To investigate the clinical significance of the serum inflammatory cytokines and the blood granulocytes/lymphocytes (G/L) ratio in patients with colorectal cancer. Methods: Forty-six patients underwent surgery for colorectal cancer. The G/L ratio and serum inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, tumour necrosis factor-α (TNF-α), granulocyte colony-stimulating factor and macrophage colony-stimulating factor (M-CSF) were measured before surgery and correlated with the Tumour Node Metastasis classification and overall survival. Results: Serum IL-6 in T3-4, N1-2, M1 cases and cancer stages III-IV sub-groups was significantly higher than in Tis-2, N0, M0 and cancer stages 0-II sub-groups. The G/L ratio, serum M-CSF and TNF-α in T3-4 cases were significantly higher than in Tis-2 cases. Furthermore, the G/L ratio and serum IL-6 showed a significant inverse correlation with the overall survival, while the G/L ratio showed a significant positive correlation with serum IL-6, TNF-α and M-CSF. Multivariate analysis showed that the serum IL-6 level and G/L ratio were independent risk factors for poor prognosis. Conclusions: In this investigation, a pre-operative high level of serum IL-6 and the G/L ratio appeared to be significant predictive factors for cancer progression and poor prognosis. Accordingly, these variables might be clinically relevant biomarkers in patients with colorectal cancer.

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Section: Discussionsupporting

confidence: 81%

“…We thought that the relative ratio of granulocytes and lymphocytes might relate to the state of the host's anti-cancer immunity. In line with this thinking, we previously found that the blood granulocytes/lymphocytes (G/L) ratio was a relevant parameter to assess the stress state [9]. …”

Section: Introductionmentioning

confidence: 94%

In Patients with Colorectal Cancer, Preoperative Serum Interleukin-6 Level and Granulocyte/Lymphocyte Ratio Are Clinically Relevant Biomarkers of Long-Term Cancer Progression

Shimazaki¹,

Goto²,

Nishida³

et al. 2013

Oncology

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“…Tabuchi et al 13 reported that the blood granulocyteto-lymphocyte ratio is a simple and clinically relevant parameter for the assessment of perioperative stress in patients undergoing colorectal surgery. Toll-like receptors, a-defensins, highsensitivity C-reactive protein (CRP), and IL-6 have also been used as early markers to determine the inflammatory response in colorectal resection.…”

Section: Markers Of Surgical Stressmentioning

confidence: 99%

Surgical Stress Response After Colorectal Resection

Andersson

Ansari

Nordén

et al. 2013

International Surgery

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The human body's response to surgery is correlated with the extent of tissue damage. The aim of the present study was to, over time, map out parameters concerning inflammation, metabolism, nutrition, breathing function, muscle strength, and well-being in elective colorectal surgery. Eighteen patients were prospectively included: colon resection (n ¼ 9) and rectum resection/amputation (n ¼ 9). Postoperative interleukin 10 (IL-10) rose more in the rectum surgery group on day 0 (P ¼ 0.007) and day 3 (P ¼ 0.025). Furthermore, significant differences between groups were detected regarding albumin, prealbumin, and total iron-binding capacity (TIBC). For albumin and TIBC, this difference was seen even on day 7. C-reactive protein, IL-6, IL-8, glucose, cortisol, insulin, pain, fatigue, nausea, grip strength, and forced expiratory volume in 1 second did not show any differences. No correlation was revealed between measured parameters and postoperative complications. Postoperative levels of IL-10, albumin, prealbumin, and TIBC may be used as determinants of surgical stress after colorectal surgery.

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“…Particularly when it is intense and persistent, the stress response may transform from an adaptive and protective role into a pathological phenomenon, and may even result in perioperative complications and mortality (2). Thus, a number of studies have attempted to alleviate stress damage, for example by afferent blocking of nociceptive stimulus or regulating humoral factors (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Effect of intercostal nerve block combined with general anesthesia on the stress response in patients undergoing minimally invasive mitral valve surgery

Yang

Guo

Huang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the effect of intercostal nerve block combined with general anesthesia on the stress response and postoperative recovery in patients undergoing minimally invasive mitral valve surgery (MIMVS). A total of 30 patients scheduled for MIMVS were randomly divided into two groups (n=15 each): Group A, which received intercostal nerve block combined with general anesthesia and group B, which received general anesthesia alone. Intercostal nerve block in group A was performed with 0

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The perioperative granulocyte/lymphocyte ratio is a clinically relevant marker of surgical stress in patients with colorectal cancer

Cited by 28 publications

References 36 publications

In Patients with Colorectal Cancer, Preoperative Serum Interleukin-6 Level and Granulocyte/Lymphocyte Ratio Are Clinically Relevant Biomarkers of Long-Term Cancer Progression

In Patients with Colorectal Cancer, Preoperative Serum Interleukin-6 Level and Granulocyte/Lymphocyte Ratio Are Clinically Relevant Biomarkers of Long-Term Cancer Progression

Surgical Stress Response After Colorectal Resection

Effect of intercostal nerve block combined with general anesthesia on the stress response in patients undergoing minimally invasive mitral valve surgery

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