The Peritoneal Immune System and Continuous Ambulatory Peritoneal Dialysis

Rapoport, Jayson; Hausmann, MichaelJ.; Chaimovitz, Cidio

doi:10.1159/000045319

Cited by 27 publications

(20 citation statements)

References 41 publications

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“…Mesothelin levels were not raised even in patients undergoing continuous ambulatory peritoneal dialysis in which a marked reactive mesothelial cell proliferation is characteristically seen in the peritoneal fluid. 24 Although this confirms that reactive mesothelial cells in this clinical situation do not release large amounts of mesothelin into the fluid, it is possible that mesothelin protein would not have had time to accumulate into the dialysate or, indeed, if the dialysate dilutes mesothelin concentrations beyond the detection levels of this assay. Patients with ovarian cancer, which has a number of biological similarities to mesothelioma and who also exhibit raised serum levels of mesothelin, 25 also exhibit raised levels of mesothelin in the peritoneal fluid.…”

Section: Discussionmentioning

confidence: 56%

Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma

Creaney

Yeoman

Naumoff

et al. 2007

Thorax

112

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Background: The diagnosis of malignant mesothelioma is frequently difficult, the most common differential diagnosis being reactive pleural conditions and metastatic adenocarcinoma. Soluble mesothelin levels in serum have recently been shown to be highly specific and moderately sensitive for mesothelioma. As most patients with mesothelioma present with exudative effusions of either the pleura or the peritoneum, a study was undertaken to determine if levels of mesothelin were raised in these fluids and if the increased levels could help to distinguish mesothelioma from other causes of exudative effusion. Methods: Pleural fluid was collected from 192 patients who presented to respiratory clinics (52 with malignant mesothelioma, 56 with non-mesotheliomatous malignancies and 84 with effusions of nonneoplastic origin). Peritoneal fluid was collected from 42 patients (7 with mesothelioma, 14 with nonmesotheliomatous malignancies and 21 with benign effusions). Mesothelin levels were determined in effusion and serum samples by ELISA. Results: Significantly higher levels of mesothelin were found in effusions of patients with mesothelioma; with a specificity of 98%, the assay had a sensitivity of 67% comparing patients with mesothelioma and those with effusions of non-neoplastic origin. In 7 out of 10 cases mesothelin levels were raised in the effusion collected 3 weeks to 10 months before the diagnosis of mesothelioma was made; in 4 out of 8 of these, mesothelin levels were increased in the effusion but not in the serum. Conclusions: Measurement of mesothelin concentrations in the pleural and/or peritoneal effusion of patients may aid in the differential diagnosis of mesothelioma in patients presenting with effusions.

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Section: Discussionmentioning

confidence: 56%

Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma

Creaney

Yeoman

Naumoff

et al. 2007

Thorax

112

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“…Human peritoneal mesothelial cells (HPMC) 3 were isolated from the specimens of omentum obtained from consenting patients undergoing elective abdominal surgery. Cells were isolated and characterized as described in detail elsewhere (31,32).…”

Section: Peritoneal Mesothelial Cell Culturementioning

confidence: 99%

“…The role of other leukocyte populations in peritoneal immunity is, however, less understood. In healthy individuals, 5-10% of peritoneal leukocytes are lymphocytes, with the vast majority belonging to the T lineage (3,4). It has been suggested that the specific peritoneal microenvironment may affect T cell selection in the peritoneum (5).…”

mentioning

confidence: 99%

IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GROα Chemokine from Mesothelial Cells

Witowski

Pawlaczyk

Bręborowicz

et al. 2000

The Journal of Immunology

286

232

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IL-17 is a newly discovered cytokine implicated in the regulation of hemopoiesis and inflammation. Because IL-17 production is restricted to activated T lymphocytes, the effects exerted by IL-17 may help one to understand the contribution of T cells to the inflammatory response. We investigated the role of IL-17 in leukocyte recruitment into the peritoneal cavity. Leukocyte infiltration in vivo was assessed in BALB/Cj mice. Effects of IL-17 on chemokine generation in vitro were examined in human peritoneal mesothelial cells (HPMC). Administration of IL-17 i.p. resulted in a selective recruitment of neutrophils into the peritoneum and increased levels of KC chemokine (murine homologue of human growth-related oncogene α (GROα). Pretreatment with anti-KC Ab significantly reduced the IL-17-driven neutrophil accumulation. Primary cultures of HPMC expressed IL-17 receptor mRNA. Exposure of HPMC to IL-17 led to a dose- and time-dependent induction of GROα mRNA and protein. Combination of IL-17 together with TNF-α resulted in an increased stability of GROα mRNA and synergistic release of GROα protein. Anti-IL-17 Ab blocked the effects of IL-17 in vitro and in vivo. IL-17 is capable of selectively recruiting neutrophils into the peritoneal cavity via the release of neutrophil-specific chemokines from the peritoneal mesothelium.

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“…The whole-body irradiation produces a depletion of NK cells and NK activity; recovery occurs within 10 weeks (Silobrcic et al, 1990). This treatment was essential for the experiments conducted here because of the high content of NK cells in the peritoneal sera (Rapoport et al, 1999).…”

Section: Mice and Animal Irradiationmentioning

confidence: 99%

A nude mice model of human rhabdomyosarcoma lung metastases for evaluating the role of polysialic acids in the metastatic process

Daniel

Durbec²,

Gautherot³

et al. 2001

Oncogene

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PSA is an oncodevelopmental antigen usually expressed in human tumors with high metastatic potential. Here we set up a metastatic model in nude mice by using TE671 cells, which strongly express PSA-NCAM. We observed the formation of lung metastases when TE671 cells were injected intravenously, intramuscularly, and intraperitoneously, but not subcutaneously. Intraperitoneous injections also induced peritoneal carcinosis, ascites, and liver metastases. To evaluate the putative role of PSA in the metastatic process we used a speci®c cleavage of PSA on NCAM by endoneuraminidase-N on intraperitoneous primary tumors. Mice with primary intramuscular tumors were taken as control. Repeated injections of endoneuraminidase-N led to a decrease in PSA expression in primary intraperitoneous nodules and ascites but not in intramuscular primary tumors. Endoneuraminidase-N also increased the delay in ascitic formation and decreased the number of lung or liver metastases in the case of intraperitoneous tumors but not in the case of intramuscular tumors. When metastases occurred in endoneuraminidase-N injected animals, they strongly expressed PSA-NCAM. Therefore, we established a relationship between PSA expression on the surface of primary tumor cells and the metastatic process. Oncogene (2001) 20, 997 ± 1004.

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The Peritoneal Immune System and Continuous Ambulatory Peritoneal Dialysis

Cited by 27 publications

References 41 publications

Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma

Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma

IL-17 Stimulates Intraperitoneal Neutrophil Infiltration Through the Release of GROα Chemokine from Mesothelial Cells

A nude mice model of human rhabdomyosarcoma lung metastases for evaluating the role of polysialic acids in the metastatic process

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