The Perivascular Space Race

Perivascular Spaces

“…One of the most intriguing hypotheses linking PVS with dementia risk is that they may reflect processes that impair drainage of soluble amyloid from the brain, causing amyloid to accumulate and deposit in the cerebral arteries and parenchyma. 4 Recent research indicates that, in addition to stratifying dementia risk, PVS severity and location provide clinically useful information that can be used to distinguish cerebral amyloid angiopathy (CAA) from deep perforator (hypertensive) arteriopathy. In CAA, higher numbers of PVS are seen in the white matter of the centrum semiovale, often just beneath the cortex, 5 whereas in deep perforator arteriopathy, more PVS are seen in the basal ganglia.…”

“…One of the most intriguing hypotheses linking PVS with dementia risk is that they may reflect processes that impair drainage of soluble amyloid from the brain, causing amyloid to accumulate and deposit in the cerebral arteries and parenchyma. 4…”