The persistence of memory: prior memory responses modulate behavior and brain state engagement

Abstract

Memory brain states may influence how we experience an event. Memory encoding and retrieval constitute neurally dissociable brain states that individuals can selectively engage based on top-down goals. To the extent that memory states linger in time - as suggested by prior behavioral work - memory states may influence not only the current experience, but also subsequent stimuli and judgments. Thus lingering memory states may have broad influences on cognition, yet this account has not been directly tested utilizing neural measures of memory states. Here we address this gap by testing the hypothesis that memory brain states are modulated by memory judgments, and that these brain states persist for several hundred milliseconds. We recorded scalp electroencephalography (EEG) while participants completed a recognition memory task. We used an independently validated multivariate mnemonic state classifier to assess memory state engagement. We replicate prior behavioral findings; however, our neural findings run counter to the predictions made on the basis of the behavioral data. Surprisingly, we find that prior responses modulate current memory state engagement on the basis of response congruency. That is, we find strong engagement of the retrieval state on incongruent trials - when a target is preceded by a correct rejection of a lure and when a lure is preceded by successful recognition of a target. These findings indicate that cortical brain states are influenced by prior judgments and suggest that a non-mnemonic, internal attention state may be recruited to in the face of changing demands in a dynamic environment.