The Perspective on Psoriatic Arthritis in Asia

Abstract

There is a wide variation in the prevalence, incidence, and clinical manifestation of psoriatic arthritis (PsA) across countries due to genetic and environmental factors. Data on PsA in Asia are limited and come from small cross-sectional studies. The burden of PsA in Asia is high, including poor physical functioning, poor quality of life, and high socioeconomic cost. In addition, high rates of subclinical atherosclerosis and traditional cardiovascular risk factors among PsA patients in Asia have been demonstrated. Preliminary data suggest treatment with tumor necrosis factor blockers may reverse atherosclerosis in PsA. Several outcome measure instruments, including the Medical Outcomes Survey Short Form 36 and Health Assessment Questionnaire, have been validated for measuring PsA burden among the Chinese. A coordinated effort in Asia from the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and the Asia Pacific League of Associations for Rheumatology (APLAR) will help estimate disease burden and clinical behavior of PsA on that continent.

Behçet’s disease in concurrence with psoriasis

“…PsA, an inflammatory arthritis which is characterized by asymmetric distribution and distal interphalangeal joint involvement, dactylitis, enthesis and spondylitis has been found in four patients (44.4%) in our study. It is noteworthy compared with the previously reported prevalence of PsA among psoriasis patients in Korea, which was 9% 40,41 . Joint involvement of BD differs from PsA by its typically non‐erosive and non‐deforming, monoarticular and intermittent characteristics usually affecting the knees or ankles 42 .…”

Predictors of functional deterioration in Chinese patients with Psoriatic arthritis: a longitudinal study

“…However, differences in clinical manifestation among Asian patients with PsA have been described[16], which limit direct extrapolation of results. These include the exceptionally low prevalence of psoriasis and PsA among Japanese[33], high prevalence of spinal involvement among Koreans[34], high percentage of asymptomatic radiographic sacroiliitis among Chinese[6, 35], and high risk among Indians with psoriasis to develop PsA as compared to Chinese[35, 36].…”

“…There were only a few studies on the longitudinal course of physical function in PsA from Caucasian countries[11, 12], while physiotherapy was shown to improve physical function in spondyloarthropathies (SpA)[13–15]. There are cultural and ethnicity differences among Asian that affect disease manifestation in PsA and SpA[16, 17], which may also affect disease progression and physical function. We hypothese that disease activities at baseline determine the physical function over time in patients suffering from PsA.…”

Clinical and anamnestic criteria of the progression of psoriasis

“…В бра-зильской популяции [22] ПсА отмечен у 33% паци-ентов с ПС. В азиатской популяции [23] распростра-ненность ПсА среди лиц с ПС значительно ниже -от 1 до 9%. Так, в китайской популяции 6% больных ПС имели ПсА, в турецкой -2%, в иранской, корей-ской и индийских популяциях -9%, в японской -1% [23].…”

“…В азиатской популяции [23] распростра-ненность ПсА среди лиц с ПС значительно ниже -от 1 до 9%. Так, в китайской популяции 6% больных ПС имели ПсА, в турецкой -2%, в иранской, корей-ской и индийских популяциях -9%, в японской -1% [23]. Такой широкий диапазон показателей рас-пространенности ПсА вероятнее всего объясняется расовыми различиями, генетическим фоном, кли-матогеографическими особенностями, а также ва-риабельностью клинической картины в дебюте за-болевания, отсутствием единых критериев диагно-стики и дифференциальной диагностики ПсА.…”