The PET-Derived Tumor-to-Liver Standard Uptake Ratio (SUVTLR) Is Superior to Tumor SUVmax in Predicting Tumor Response and Survival After Chemoradiotherapy in Patients With Locally Advanced Esophageal Cancer

Wang, Chunsheng; Zhao, Kangcheng; Hu, Shanliang; Huang, Yong; Ma, Li; Li, Minghuan; Song, Yipeng

doi:10.3389/fonc.2020.01630

Cited by 19 publications

(14 citation statements)

References 44 publications

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“…Immediately following PET imaging, mice were sacrificed and organs were isolated for residual 18 F-FDG activity measurement in a well counter. Per standard radiology procedures, organ activity was time-adjusted for decay from the time of injection, normalized to organ weight, then normalized to liver activity [40][41][42] (Figure 5). Two animals were used per time point with the exception of 40 min post-fentanyl, which represents three mice.…”

Section: Resultsmentioning

confidence: 99%

Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice

Newman,

Lynch,

Connery

et al. 2024

Basic Clin Pharma Tox

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Fentanyl exposure and overdose are growing concerns in public health and occupational safety. This study aimed to establish parameters of fentanyl lethality in SKH1 mice for future overdose research. Lethality was determined using the up‐down procedure, with subjects monitored post‐administration using pulse oximetry (5 min) and then whole‐body plethysmography (40 min). Following the determination of subcutaneous dose–response, [18F]Fluorodeoxyglucose positron emission tomography (18F‐FDG PET) was performed after LD10 fentanyl at 40 min, 6 h, 24 h or 7 days post‐dose. LD10 and LD50 were observed to be 110 and 135 mg/kg, respectively, and consistent with four‐parameter logistic fit values of 111.2 and 134.6 mg/kg (r2 = 0.9996). Overdose (LD10 or greater) yielded three distinct cardiovascular groups: survival, non‐survival with blood oxygen saturation (SpO2) minimum ≥37% and non‐survival with SpO2 <37%. Breaths per minute, minute volume and inspiratory quotient were significantly different between surviving and non‐surviving animals for up to 40 min post‐injection. 18F‐FDG PET revealed decreased glucose uptake in the heart, lungs and brain for up to 24 h. These findings provide critical insights into fentanyl lethality in SKH1 mice, including non‐invasive respiratory effects and organ‐specific impacts that are invaluable for future translational studies investigating the temporal effects of fentanyl overdose.

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Section: Resultsmentioning

confidence: 99%

Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice

Newman,

Lynch,

Connery

et al. 2024

Basic Clin Pharma Tox

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“…Because hepatic FDG metabolism and acquisition parameters on PET/CT can vary among patients, we determined the ratio between SUV max in the gallbladder and in the healthy liver, which we called TLR max . The calculation of tumor-to-liver background activity as a form of standardization has been described in other types of tumors, appearing as a more reliable parameter to distinguish between benign and malignant processes, 29,30 and a better prognostic factor [31][32][33] than SUV max , being also more reproducible among different PET scanners. In the present study, TLR max proved to have a greater statistical significance than SUV max to distinguish benign and malignant pathology.…”

Section: Discussionmentioning

confidence: 99%

Imaging Gallbladder Lesions: What Can Positron Emission Tomography/Computed Tomography Add to the Conventional Imaging Approach?

Sabaté‐Llobera

Reynés-Llompart

Mestres-Martí

et al. 2023

J Comput Assist Tomogr

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Objective: Incidental gallbladder lesions are common in imaging studies, although it is not always easy to discriminate benign lesions from gallbladder cancer with conventional imaging procedures. The present study aims to assess the capacity of positron emission tomography/computed tomography (PET/CT) with 2-[ 18 F]FDG to distinguish between benign and malignant pathology of the gallbladder, compared with conventional imaging techniques (contrast-enhanced CT or magnetic resonance imaging).Methods: Positron emission tomography/CT and conventional imaging studies of 53 patients with gallbladder lesions were evaluated and visually classified as benign, malignant, or inconclusive. Agreement between PET/ CT and conventional imaging was determined, and imaging findings were correlated with histology or follow-up. Positron emission tomography/CT images were also analyzed semiquantitatively (SUV max and maximum tumor-to-liver ratio [TLR max ]). The presence of adenopathies and distant metastases was assessed and compared between both imaging procedures.Results: According to histology or follow-up, 33 patients (62%) had a malignant process and 20 (38%) had benign lesions. Positron emission tomography/CT and conventional imaging showed a moderate agreement (κ = 0.59). Conventional imaging classified more studies as inconclusive compared with PET/CT (17.0% and 7.5%, respectively), although both procedures showed a similar accuracy. Malignant lesions had significantly higher SUV max and, especially, TLR max (0.89 and 2.38 [P = 0.00028] for benign and malignant lesions, respectively). Positron emission tomography/ CT identified more pathologic adenopathies and distant metastases, and patients with regional or distant spread had higher SUV max and TLR max in the gallbladder.Conclusions: Positron emission tomography/CT is accurate to distinguish between benign and malignant pathology of the gallbladder, with a similar performance to conventional imaging procedures but with less inconclusive results. Malignant lesions present higher SUV max and TLR max values.

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“…Among 18 F-FDG PET parameters, SUVmax, MTV and TLG have been reported to be prognostic in meta-analyses [ 10 , 53 , 54 ]. In the present study, we utilized TLR instead of SUVmax to minimize the effect of heterogeneous 18 F-FDG PET data [ 23 , 55 ]. In accordance with the literature, a high TLR score was associated with worse prognosis in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Also, the SUVmax score of the liver was calculated from each patient for normalization by drawing a 3.0-mm-diameter globular region of interest (ROI). The tumor-to-liver SUVmax ratio (TLR) was defined as the tumor SUVmax value divided by the liver SUVmax value [ 24 , 25 ]. The coefficient of variation (COV) is measured as the ratio of the standard deviation to the mean, which can be considered as a feature to reflect metabolic heterogeneity [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Prognostic impact of an integrative analysis of [18F]FDG PET parameters and infiltrating immune cell scores in lung adenocarcinoma

Choi

Sarker²,

Choi³

et al. 2022

EJNMMI Res

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Background High levels of 18F-fluorodeoxyglucose (18F-FDG) tumor uptake are associated with worse prognosis in patients with non-small cell lung cancer (NSCLC). Meanwhile, high levels of immune cell infiltration in primary tumor have been linked to better prognosis in NSCLC. We conducted this study for precisely stratified prognosis of the lung adenocarcinoma patients using the integration of 18F-FDG positron emission tomography (PET) parameters and infiltrating immune cell scores as assessed by a genomic analysis. Results Using an RNA sequencing dataset, the patients were divided into three subtype groups. Additionally, 24 different immune cell scores and cytolytic scores (CYT) were obtained. In 18F-FDG PET scans, PET parameters of the primary tumors were obtained. An ANOVA test, a Chi-square test and a correlation analysis were also conducted. A Kaplan–Meier survival analysis with the log-rank test and multivariable Cox regression test was performed to evaluate prognostic values of the parameters. The terminal respiratory unit (TRU) group demonstrated lower 18F-FDG PET parameters, more females, and lower stages than the other groups. Meanwhile, the proximal inflammatory (PI) group showed a significantly higher CYT score compared to the other groups (P = .001). Also, CYT showed a positive correlation with tumor-to-liver maximum standardized uptake value ratio (TLR) in the PI group (P = .027). A high TLR (P = .01) score of 18F-FDG PET parameters and a high T follicular helper cell (TFH) score (P = .005) of immune cell scores were associated with prognosis with opposite tendencies. Furthermore, TLR and TFH were predictive of overall survival even after adjusting for clinicopathologic features and others (P = .024 and .047). Conclusions A high TLR score was found to be associated with worse prognosis, while high CD8 T cell and TFH scores predicted better prognosis in lung adenocarcinoma. Furthermore, TLR and TFH can be used to predict prognosis independently in patients with lung adenocarcinoma.

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The PET-Derived Tumor-to-Liver Standard Uptake Ratio (SUVTLR) Is Superior to Tumor SUVmax in Predicting Tumor Response and Survival After Chemoradiotherapy in Patients With Locally Advanced Esophageal Cancer

Cited by 19 publications

References 44 publications

Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice

Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice

Imaging Gallbladder Lesions: What Can Positron Emission Tomography/Computed Tomography Add to the Conventional Imaging Approach?

Prognostic impact of an integrative analysis of [18F]FDG PET parameters and infiltrating immune cell scores in lung adenocarcinoma

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