The Petal Extract of Hibiscus sabdariffa Produces Relaxation of Isolated Rat Aorta

Obiefuna, P. C. M.; Owolabi, O. A.; Adegunloye, B. J.; Obiefuna, Idongesit; Sofola, OA

doi:10.3109/13880209409082975

Cited by 43 publications

(42 citation statements)

References 11 publications

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“…The crude hydroalcohol extract of Hibiscus sabdariffa has shown in vitro an appreciable enzyme inhibiting activity toward the angiotensin I converting enzyme (ACE) attributable to flavones (1, 8-13), but weak inhibitory activities toward elastase, trypsin, and α-chymotrypsin (Jonadet et al, 1990). The aqueous extract of the petals of Hibiscus sabdariffa caused vasorelaxation of the rat isolated aorta via both endothelium-dependent and independent mechanisms (Obiefuna et al, 1994). The vasorelaxant effect of aqueous extract of petals was mediated through inhibition of Ca 2+ influx from extracellular medium as well as inhibition of Ca 2+ release from intracellular stores (Owolabi et al, 1995).…”

Section: Antihypertensivementioning

confidence: 99%

Biologically Active Compounds from the GenusHibiscus.

Vasudeva

Sharma

2008

Pharmaceutical Biology

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Since ancient times, Hibiscus species (Malvaceae) have been used as a folk remedy for the treatment of skin diseases, as an antifertility agent, antiseptic, and carminative. Some compounds isolated from the species, such as flavonoids, phenolic acids, and polysaccharides, are considered responsible for these activities. This review aims to summarize the worldwide reported biological activities and phytoconstituents associated with this genus for the past 40 years.

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Section: Antihypertensivementioning

confidence: 99%

Biologically Active Compounds from the GenusHibiscus.

Vasudeva

Sharma

2008

Pharmaceutical Biology

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“…Reduction in the percentage transit point indicates a reduction in intestinal motility and an increase transit time (Oluwade et al, 2004). H. sabdariffa is reported to inhibit the tone of various isolated muscle preparations that included rabbit aortic strip (Obiefuna et al, 1994) and rat ileal strip (Salah et al, 2002). The extract also rhythmically contracted rat uterus, guinea-pig tracheal chain and rat diaphragm.…”

Section: Discussionmentioning

confidence: 99%

The effects of aqueous extracts of Hibiscus sabdariffa Linn. calyces of var. ruber and var. intermedius on intestinal transit in rats

Bako¹,

Mabrouk²,

Olorunshola³

et al. 2013

Afr. J. Pharm. Pharmacol.

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The effects of aqueous extracts of Hibiscus sabdariffa l. calyces of var. ruber and var. intermedius on intestinal transit were determined in experimental rats. The dried calyces of H. sabdariffa l. were pulverized and 10% extracts of both var. ruber and var. intermedius were made and administered orally at varying doses. Test rats were given the 10% extracts of both the species of H. sabdariffa at 0.5 ml/100 g,1 ml/100 g and 2 ml/100 g body weight, while control rats received normal saline. After 30 min, each animal was then given 1.5 ml of the dye solution orally. About 1 h after administering the dye, each rat was sacrificed and the intestine carefully dissected out. The length of the intestine and the transit point of the orally administered dye were then measured. The transit point was calculated as a percentage of the total length of the intestine. The extracts of both var. ruber and var. intermedius of H. sabdariffa l. caused a reduction in transit points of the dye. The extract of var. intermedius was more effective than var. ruber. The reduction in transit point and the increase in transit time by both extracts indicates that the plant possess astringent effect and could be used at appropriate dose as constipating agent or for stabilizing diarrhea. The acute toxicity study of H. sabdariffa l. in rats was found to be above 5,000 mg kg -1 .

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“…The crude extract was prepared according to the method described by [19]. The leaves were oven dried at 45°C and hundred grams of the dried fruit materials was pulverized and soaked for 72hours in 800mls of distilled water.…”

Section: Materials and Methods Samplesmentioning

confidence: 99%