The pH dependent absorption of propranolol and indomethacin by Parafilm, a stimulant of salivary secretion

Taylor, Elizabeth A.; Kaspi, T; Turner, Paul

doi:10.1111/j.2042-7158.1978.tb13405.x

Cited by 10 publications

(2 citation statements)

References 7 publications

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“…Naturally, any stimulus on salivation must not absorb, modify or interfere with the substances of interest. In particular, Parafilm ® absorbs lipophilic substances, causing false low results in analytics [39]. Moreover, acidic stimulation may cause problems when using immunoassays for analysis [40].…”

Section: Review Gröschlmentioning

confidence: 99%

Saliva: A Reliable Sample Matrix in Bioanalytics

Gröschl¹

2017

Bioanalysis

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Saliva is gaining increasing attention as a bioanalytical sample matrix. Mostly because of the easy and noninvasive collection, it is not only beneficial in endocrinological and behavioral science, but also in pediatrics. Saliva also has the advantage of being the only body fluid which can be collected even during physical exercise, for example, during sportive activities, and there are physiological characteristics that make it superior to serum/plasma or urine for specific scientific questions. This review provides an insight into the physiology of saliva formation, explaining how certain compounds enter this bodily fluid, and gives advice for collection, storage and analytical methods. Finally, it presents a number of reliable and proven applications for saliva analysis from scientific fields including endocrinology, sports medicine, forensics and immunology.

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Section: Review Gröschlmentioning

confidence: 99%

Saliva: A Reliable Sample Matrix in Bioanalytics

Gröschl¹

2017

Bioanalysis

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“…After drug quantitation in plasma and saliva, acebutolol and its acetyl analogue S/P ratios were calculated for each subject, for each collection procedure and at each collection time. Although Parafilm drug binding has been shown to occur with propranolol and thus to slightly modify its measured salivary levels (Taylor, Kaspi & Turner, 1978), this possibility can probably be ruled out in the case of acebutolol which is much less lipid soluble than propranolol. Mean plasma peak values for acebutolol (536 + 87 ng/ml) and its acetyl analogue (910 117 ng/ml) were reached respectively 2 and 4 h after acebutolol administration.…”

Section: Acebutolol Saliva Excretionmentioning

confidence: 99%