2017
DOI: 10.1002/sia.6244
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The pH dependent interaction between nicotine and simulated pulmonary surfactant monolayers with associated molecular modelling

Abstract: Pulmonary surfactant is an endogenous material that lines and stabilises the alveolar air-liquid interface. Respiratory mechanics can be compromised by exposure to environmental toxins such as cigarette smoke, which contains nicotine. This study aims to determine the influence of nicotine on the activity of simulated lung surfactant at pH 7 and pH 9. In all cases, the addition of nicotine to the test zone caused deviation in surfactant film performance. Importantly, the maximum surface pressure was reduced for… Show more

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Cited by 5 publications
(6 citation statements)
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“…On inspection of the data presented in Figure , it is evident that compression of the mixed monolayer system led to an increase in the surface pressure term throughout. In all cases, smooth traces are apparent and are in line with previously acquired data . Clear gradient changes within each curve reflect phase transitions within the 2‐dimensional ensemble .…”
Section: Resultsmentioning
confidence: 99%
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“…On inspection of the data presented in Figure , it is evident that compression of the mixed monolayer system led to an increase in the surface pressure term throughout. In all cases, smooth traces are apparent and are in line with previously acquired data . Clear gradient changes within each curve reflect phase transitions within the 2‐dimensional ensemble .…”
Section: Resultsmentioning
confidence: 99%
“…Variation in the monomolecular structure results further to drug partitioning with either the drug causing expanded regions to become more condensed in nature via insertion within accessible areas or direct interaction between drug molecule and surfactant components, as modelled herein. Such modification to the surfactant film in the (deep) lung can influence structure‐function activity; however, in general terms, the surfactant film appears robust and resilient to external stressors (ie, drug substances and environmental toxins), and this allows it to fulfil its crucial biological function.…”
Section: Resultsmentioning
confidence: 99%
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