The pH test paper: a tool for distinguishing between the cerebrospinal fluid and saline

Quantitation of osimertinib, alectinib and lorlatinib in human cerebrospinal fluid by UPLC-MS/MS

“…However, aqueous solubility of all compounds is comparable in CSF (i.e. at pH 7.3) [31][32][33][34]. Furthermore, lorlatinib and osimertinib have comparable acidity, with a pK a of 4.9 and 4.4 (aniline) respectively [33,34].…”