The pharmaceutical industry and natural products: historical status and new trends

David, Bruno; Wolfender, Jean‐Luc; Dias, Daniel A.

doi:10.1007/s11101-014-9367-z

Cited by 466 publications

(291 citation statements)

References 92 publications

(113 reference statements)

Supporting

Mentioning

281

Contrasting

Unclassified

Order By: Relevance

“…1 According to World Health Organization (WHO), herbal medicines are defined as plant-derived material or preparations with therapeutic or other human health benefits which contain either raw or processed ingredients from one or more plants. 2 Traditional medicines are considered as first line treatment in many tribes and have potential to treat several diseases.…”

Section: Introductionmentioning

confidence: 99%

Quality Control standardization of Wild Himalayan Pear: Pyrus pashia

Hemalatha¹,

Sharma²,

Prasad³

2016

Phcogj

View full text Add to dashboard Cite

Introduction: To establish the pharmacognostical and phytochemical standardization parameters of Pyrus pashia fruits in order to ensure quality and safety of this traditionally acclaimed medicinal tree. Methods: The fresh fruits of P. pashia were collected and dried. Fruit was subjected to various pharmacognostical investigations, Extraction procedures, and preliminary phytochemical screening, according to WHO guidelines. Ethanolic extract was standardized to total phenolic and flavonoid content, followed by phyto chemical quantification of P. pashia extract using lupeol as a chemical marker by HPLC method. Results: In the present study, microscopy of the fruit showed typical characteristics of berry, having thick fleshy pericarp differentiated into thin epicarp and thick mesocarp having wide radiating carpel chambers with one or two seeds attached in axile placentum. Further, physicochemical evaluation was done like, loss on drying, total ash value, acid insoluble ash value, water soluble ash value, fluorescence analysis etc. Heavy metal and pesticide residue analysis was also performed. Furthermore, ethanolic extract of Pyrus pashia (EPP) obtained from cold maceration and phytochemical screening of different fractions obtained by

show abstract

Section: Introductionmentioning

confidence: 99%

Quality Control standardization of Wild Himalayan Pear: Pyrus pashia

Hemalatha¹,

Sharma²,

Prasad³

2016

Phcogj

View full text Add to dashboard Cite

show abstract

“…The interest of pharmaceutical companies in natural products as a source of drugs has grown notoriously, mostly in low income countries. 34 Essential oils can inhibit the DENV replication in vitro; thus, they offer a great opportunity to find novel compounds as starting points towards discovery of drug to treat dengue. This work has explored the potentials of synthetic-derived essential oils compounds to inhibit the DENV replication in vitro.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus

Flechas¹,

Ocazionez²,

Stashenko³

2017

View full text Add to dashboard Cite

Introduction:There are not effective drugs available for treatment of dengue fever despite intensive research on synthetic inhibitors. The search for active phytochemicals could serve for the discovery of new drugs. This study aims to evaluate the antiviral activity in vitro of compounds found in essential oils from medicinal plants. Materials and Methods: Nine synthetic-derived essential oil compounds were evaluated. Antiviral effect was screened measuring the reduction of viral NS1 and E proteins in HepG-2 and Vero cells. Results: β-Caryophyllene was identified as the most active compound, it reduced the virus serotype-2 replication in HepG-2 cells at IC 50 of 22 ± 5.6 µM, and blocked replication of all four serotypes in Vero cells at IC 50 between 8.0 µM and 15.0 µM. The selectivity indexes were between 5.3 and 10. According to results from time-in-addition assays, the antiviral effect of β-caryophyllene appears to be associated with interruption of early steps of the virus life cycle. Citral revealed modest antiviral effect, it reduced the virus serotype-2 (IC 50 of 31 ± 4.5 µM) replication but not the other three serotypes. Seven terpenes did not reveal antiviral activity at maximum concentration of 30 µM. Conclusion: Research on compounds found in essential oils can contribute to the drug discovery effort for dengue. β-Caryophyllene could serve as a starting point.

show abstract

“…For example, there are often relatively meager yields compared to enormous investments by pharmaceutical companies attempting to identify and isolate potential drugs from nature. The experience of such limited results suffered by pharmaceutical industry, which has invested in extensive and continual research to identify, to isolate, and to industrialize naturally occurring chemical substances, may have indirectly contributed to the lack of investments in the prospection and use of natural products by shipping industry [77].…”

Section: Discussionmentioning

confidence: 99%

Which Ballast Water Management System Will You Put Aboard? Remnant Anxieties: A Mini-Review

Batista

Fernandes

Lopes³

et al. 2017

Environments

View full text Add to dashboard Cite

An accepted solution to the environmental problems related to a ship's ballast water has been the adoption and proper utilization of approved onboard ballast water plans and management systems (BWMS). On 8 September 2017, the International Maritime Organization Ballast Water Management Convention comes into force, and under this Convention, ships engaged in international trade must have an approved BWMS aboard to discharge ballast water, reducing species transfer. In response to enormous global concern about this problem, the overwhelming majority of the BWMS, approved currently for use by International Maritime Organization (IMO) and United States Coast Guard, utilize two main technologies (electro-chlorination or ultraviolet irradiation) as their principle mode of disinfection, often used in combination with filtration. However, both technologies have been questioned regarding their practically, efficiency, and possible environmental impacts upon discharge. This review article aims to explore some questions about these two technologies, drawing attention to some current uncertainties associated with their use. Also, it draws attention to some technical obstacles and regulatory impediments related to the new development of green biocide technology, which largely has been ignored, despite its potential as a simpler, cleaner and effective technology.

show abstract

The pharmaceutical industry and natural products: historical status and new trends

Abstract: Owing to the high diversity of terrestrial and marine organisms, natural products (secondary metabolites)

Cited by 466 publications

References 92 publications

Quality Control standardization of Wild Himalayan Pear: Pyrus pashia

Quality Control standardization of Wild Himalayan Pear: Pyrus pashia

Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus

Which Ballast Water Management System Will You Put Aboard? Remnant Anxieties: A Mini-Review

Contact Info

Product

Resources

About