The pharmaco-toxicological conundrum of oleander: Potential role of gut microbiome

Dey, Priyankar

doi:10.1016/j.biopha.2020.110422

Cited by 26 publications

(13 citation statements)

References 118 publications

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“…Detection efficiency has been improved by a combination of electrospray ionization with MS, owing to the gentle ionization under atmospheric pressure conditions. CGs may be analyzed even in complex human matrices in MRM mode ( Dey, 2020 ). Owing to the sensitivity and specificity of LC-MS technology, attempts were made to use this method in as early as 1993 to confirm oleandrin in decayed human tissues ( Rule et al, 1993 ).…”

Section: Detection Methodsmentioning

confidence: 99%

“…However, little is known about the pharmacokinetic behavior of oleandrin in animals, especially humans, since only a few poisoning cases and sporadic animal experiments have been analyzed. To date, the reported pharmacokinetic characteristics of some CGs are closely related to their physicochemical properties, formulations, individual gene polymorphism such as the expression of P-glycoprotein (P-gp) ( Caloni et al, 2012 ; Zhou et al, 2019 ), and the composition of the gut microbiota ( Zhang et al, 2018 ; Dey, 2020 ). The pharmacokinetic characteristics and influencing factors of oleandrin collected by various studies are summarized in Figures 2 , 3B .…”

Section: Pharmacokineticsmentioning

confidence: 99%

“…Nerium oleander , a commonly cultivated ornamental shrub of the Dogbane family, Apocynaceae ( Bandara et al, 2010 ), known as oleander, is well-known for its extensive pharmacological activities and acute toxicity ( Dey, 2020 ). Varieties of oleander are widely distributed in tropical and subtropical regions, and it is native to the Mediterranean regions of Africa and Europe ( Shepherd, 2004 ; Bandara et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…To date, only poisoning cases and sporadic animal experiments provide a basis for an in-depth understanding of the pharmacokinetic properties of oleandrin in vivo . The physicochemical properties, formulations of oleandrin, individual genetic polymorphisms, and the composition of gut microbiota appear to have significant effects on the pharmacokinetic behavior of oleandrin ( Zhou et al, 2019 ; Dey, 2020 ). Through modern preparation techniques and personalized medicine, understanding the pharmacokinetic behavior of oleandrin may provide effective strategies for solving the pharmacological issues currently associated with oleandrin.…”

Section: Introductionmentioning

confidence: 99%

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Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology

et al. 2022

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Oleandrin is a highly lipid-soluble cardiac glycoside isolated from the plant Nerium oleander (Apocynaceae) and is used as a traditional herbal medicine due to its excellent pharmacological properties. It is widely applied for various disease treatments, such as congestive heart failure. Recently, oleandrin has attracted widespread attention due to its extensive anti-cancer and novel anti-viral effects. However, oleandrin has a narrow therapeutic window and exhibits various toxicities, especially typical cardiotoxicity, which is often fatal. This severe toxicity and low polarity have significantly hindered its application in the clinic. This review describes natural sources, structural properties, and detection methods of oleandrin. Based on reported poisoning cases and sporadic animal experiments, the pharmacokinetic characteristics of oleandrin are summarized, so as to infer some possible phenomena, such as enterohepatic circulation. Moreover, the relevant factors affecting the pharmacokinetics of oleandrin are analyzed, and some research approaches that may ameliorate the pharmacokinetic behavior of oleandrin are proposed. With the toxicology of oleandrin being thoroughly reviewed, the development of safe clinical applications of oleandrin may be possible given potential research strategies to decrease toxicity.

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Section: Detection Methodsmentioning

confidence: 99%

Section: Pharmacokineticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology

et al. 2022

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“…Nerium oleander L., commonly known as oleander, is an ornamental shrub with both pharmacological and toxicological properties, whose parts have been used in ethnomedicine since ancient times as natural remedies against cardiac illnesses, cancer, diabetes, asthma, skin diseases, inflammation, etc. [1]. Oleander extracts need to be regarded with caution as they are poisonous in high doses, having important cardiotoxic effects [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells

2020

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Oleandrin, the main component of Nerium oleander L. extracts, is a cardiotoxic glycoside with multiple pharmacological implications, having potential anti-tumoral and antiviral characteristics. Although it is accepted that the main mechanism of oleandrin action is the inhibition of Na+/K+-ATPases and subsequent increase in cell calcium, many aspects which determine oleandrin cytotoxicity remain elusive. In this study, we used the model Saccharomyces cerevisiae to unravel new elements accounting for oleandrin toxicity. Using cells expressing the Ca2+-sensitive photoprotein aequorin, we found that oleandrin exposure resulted in Ca2+ influx into the cytosol and that failing to pump Ca2+ from the cytosol to the vacuole increased oleandrin toxicity. We also found that oleandrin exposure induced Mn2+ accumulation by yeast cells via the plasma membrane Smf1 and that mutants with defects in Mn2+ homeostasis are oleandrin-hypersensitive. Our data suggest that combining oleandrin with agents which alter Ca2+ or Mn2+ uptake may be a way of controlling oleandrin toxicity.

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Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations

Baranwal

Gupta

Dey

et al. 2021

Phytotherapy Research

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Uncontrolled inflammatory responses or cytokine storm associated with viral infections results in deleterious consequences such as vascular leakage, severe hemorrhage, shock, immune paralysis, multi‐organ failure, and even death. With the emerging new viral infections and lack of effective prophylactic vaccines, evidence‐based complementary strategies that limit viral infection‐mediated hyperinflammatory responses could be a promising approach to limit host tissue injury. The present review emphasizes the potentials of antiinflammatory phytochemicals in limiting hyperinflammatory injury caused by viral infections. The predominant phytochemicals along with their mechanism in limiting hyperimmune and pro‐inflammatory responses under viral infection have been reviewed comprehensively. How certain phytochemicals can be effective in limiting hyper‐inflammatory response indirectly by favorably modulating gut microbiota and maintaining a functional intestinal barrier has also been presented. Finally, we have discussed improved systemic bioavailability of phytochemicals, efficient delivery strategies, and safety measures for effective antiinflammatory phytotherapies, in addition to emphasizing the requirement of tightly controlled clinical studies to establish the antiinflammatory efficacy of the phytochemicals. Collectively, the review provides a scooping overview on the potentials of bioactive phytochemicals to mitigate pro‐inflammatory injury associated with viral infections.

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The pharmaco-toxicological conundrum of oleander: Potential role of gut microbiome

Cited by 26 publications

References 118 publications

Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology

Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology

Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells

Antiinflammatory phytochemicals against virus‐induced hyperinflammatory responses: Scope, rationale, application, and limitations

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