1996
DOI: 10.1097/00132586-199612000-00041
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The Pharmacodynamic Interaction of Propofol and Alfentanil During Lower Abdominal Surgery in Women

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Cited by 28 publications
(28 citation statements)
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“…Pharmacodynamic interactions have been described previously for propofol and alfentanil infusions. Propofol reduces opioid requirements in response to surgical stimuli [6] and alfentanil enhances the haemodynamic effects of propofol [7]. It is possible therefore that there is a strong pharmacodynamic interaction between propofol and remifentanil in terms of respiratory depression.…”
Section: Discussionmentioning
confidence: 99%
“…Pharmacodynamic interactions have been described previously for propofol and alfentanil infusions. Propofol reduces opioid requirements in response to surgical stimuli [6] and alfentanil enhances the haemodynamic effects of propofol [7]. It is possible therefore that there is a strong pharmacodynamic interaction between propofol and remifentanil in terms of respiratory depression.…”
Section: Discussionmentioning
confidence: 99%
“…Vuyk et al recently evaluated the pharmacodynamic interaction of alfentanil and propofol for lower abdominal surgery, and demonstrated that, by increasing the plasma concentration of alfentanil from 50 to 150 ng. ml -t, the effective concentration (ECs0) of propofol for the regaining of consciousness decreased from 3.8 to 0.8 lag-rnl-l. 17 Although the pharmacodynamic interaction between propofol and alfentanil was found to be nonlinear, the different amounts of opioid used in the above studies would have had an important influence on propofol requirements, in addition to the effects of midazolam. It is important to appreciate that, in our study, although the loading dose and infusion scheme of alfentanil was not computer-driven to achieve a specific target concentration, the infusion regimen was carefully standardized in an attempt to minimize the effects of varying opioid concentrations as a potential confounding variable.…”
Section: Midazolam/propofol Co-inductionmentioning
confidence: 97%
“…They are therefore often used concomitantly to attenuate the haemodynamic response to intubation. 19 This study illustrates that additional measures should be taken to contain increases in heart rate in patients in whom increases may be detrimental, i.e. ischaemic heart disease.…”
Section: Discussionmentioning
confidence: 87%