The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration

Umigai, Naofumi; Murakami, Katsuyuki; Ulit, M.V.; Antonio, L.S.; Shirotori, M.; Morikawa, Hajime; Nakano, Tetsuo

doi:10.1016/j.phymed.2010.10.019

Cited by 95 publications

(88 citation statements)

References 19 publications

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“…Many studies have demonstrated various pharmacological effects of saffron and or its important compounds including antioxidant activity, anti tumor, memory and learning enhancing, treatment of hepatic disorders, anti inflammatory, anti depressant and insulin resistant reducing (Sanchez-Vioque et al 2012;Makhlouf et al 2011;Umigai et al 2011;Ghadrdoost et al 2011;Amin et al 2011;Dhar et al 2009;Nkhaei et al 2008;Ochiai et al 2007;Soeda et al 2007;Abdullaev and Espinosa-Aguirre 2004). All these properties have been attributed to the stigmas, the sole commercially valuable part of the plant whereas other parts of the plant have been much less studied.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

et al. 2014

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Saffron (Crocus sativus L. stigma), the most valuable medicinal food product, belongs to the Iridaceae family which has been widely used as a coloring and flavoring agent. These properties are basically related to its crocins, picrocrocin and safranal contents which have all demonstrated health promoting properties. The present review article highlights the phytochemical constituents (phenolic and flavonoid compounds, degraded carotenoid compounds crocins and crocetin) that are important in antioxidant activity of saffron extracts. However, the synergistic effect of all the bioactive components presence in saffron gave a significant antioxidant activity similar to vegetables rich in carotenoids. Our study provides an updated overview focused on the antioxidant activity of saffron related to its bioactive compounds to design the different functional products in food, medicine and cosmetic industries.

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Section: Introductionmentioning

confidence: 99%

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

et al. 2014

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“…Crocetin directly acts on melanocytes and is considered to suppress melanin synthesis in a human epidermis model. The plasma concentration of crocetin when taking 7.5 mg of crocetin orally is reported to be approximately 0.1 μg/mL [13]. This experiment found that tyrosinase activity is significantly inhibited with an intake of 0.1 μg/mL crocetin.…”

Section: Discussionmentioning

confidence: 81%

“…Moreover, effects of suppressing the obstacle of the eye by light [11] and improving sleep disorders [12] have been reported. Furthermore, it is reported that crocetins are easily absorbed by the body and that concentrations in the blood reach a maximum at approximately 4 h after absorption, as opposed to lutein, which belongs to the xanthophylls, or β-carotene, which belongs to the carotenes and is the same type of carotenoid as crocetin [13]. This paper aimed to examine the mechanism of action of crocetin extracted from the fruits of Gardenia jasminoides in improving lentigines in the skin via (1) a study on adult women and (2) examination of cultured cells.…”

Section: Introductionmentioning

confidence: 99%

Improvement of Lentigines by Oral Crocetin Administration and Examination of Its Mechanism of Action

Zeng¹,

Gu²,

Umigai³

et al. 2017

J Nutr Food Sci

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We investigated the effect of crocetin, a carotenoid present in the fruits of Gardenia jasminoides, on the improvement of lentigines in the skin and examined its mechanism of action. Subjects consumed an experimental meal consisting of a drink containing 7.5 mg of crocetin daily after dinner for 8 weeks. We examined the effects of oral ingestion of crocetin on the improvement of the size of lentigines on the skin. In an epidermis model in which crocetin was added at concentrations of 1 μg/mL and 2 μg/mL and cultured for 14 days, melanin was significantly suppressed compared with the control. Investigation of the mechanism of action via a cultured human epidermis model and cultured pigment cells revealed that crocetin decreased melanocortin receptor subtype 1 of melanocytes at the messenger ribonucleic acid level and inhibited the stimulatory action of melanocytes via melanocyte-stimulating hormone. The results of the study concluded that crocetin inhibits melanin synthesis by controlling the synthesis of tyrosinase and tyrosinase-related protein-1 via the suppression of melanocortin receptor subtype 1 expression.

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“…In rat, crocetin distributed in plasma at 0.14 mM and in brain at about 40 μM by oral administration of crocetin (at a dose of 100 mg/kg) and reduced oxidative stress in brain [19]. In our previous paper, the mean peak of serum concentration of crocetin was 0.2 µg/ml (about 0.6 mM: calculated by the body weight) when healthy volunteers were administrated crocetin at a single oral dose 15 mg [21].…”

Section: Discussionmentioning

confidence: 91%

Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells

Yoshino¹,

Ishisaka²,

Umigai³

et al. 2014

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Crocetin is an aglycon of carotenoid extracted by saffron stigmas (Crocus sativus L.) and known to have a potent anti-oxidative effect. Amyliod β (Aβ), hallmark of Alzheimer's disease, is reported to have neurotoxicity partly via oxidative stress. In this study, we investigated the effect of crocetin on hippocampal HT22 cell death induced by Aβ 1-42 . Furthermore, to clarify the mechanism underlying the protective effects of crocetin against Aβ 1-42 -induced cell death, we measured reactive oxygen species (ROS) production by CM-H 2 DCFDA kit assay. Crocetin at 1 -10 μM protected HT22 cells against Aβ 1-42 -induced neuronal cell death and decreased ROS production increased by Aβ 1-42 . These results that crocetin has the potent neuroprotective effect against Aβ 1-42 -induced cytotoxicity in hippocampal cells by attenuating oxidative stress, suggest that crocetin may provide a useful therapeutic strategy against Aβ-related disorders.

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The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration

Cited by 95 publications

References 19 publications

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

Improvement of Lentigines by Oral Crocetin Administration and Examination of Its Mechanism of Action

Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells

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The pharmacokinetic profile of crocetin in healthy adult human volunteers after a single oral administration

Cited by 95 publications

References 19 publications

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

Improvement of Lentigines by Oral Crocetin Administration and Examination of Its Mechanism of Action

Crocetin Prevents Amyloid &lt;i&gt;β&lt;/i&gt;&lt;sub&gt;1-42&lt;/sub&gt;-Induced Cell Death in Murine Hippocampal Cells

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Crocetin Prevents Amyloid <i>β</i><sub>1-42</sub>-Induced Cell Death in Murine Hippocampal Cells