The pharmacokinetic profile of methylphenidate use in pregnancy: A study in mice

Peters, Haley; Strange, Lauren G.; Brown, Stacy D.; Pond, Brooks B.

doi:10.1016/j.ntt.2016.01.002

Cited by 8 publications

(1 citation statement)

References 7 publications

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“…Recently, Peters and colleagues showed that methylphenidate crosses the placenta of mice and reaches measurable concentrations in fetal brain [68]. In our study we were able to show, that methylphenidate passes the human placenta as well.…”

Section: Discussionsupporting

confidence: 70%

Detection of drugs in paired maternal and umbilical cord blood samples

Veit¹,

Erdmann²,

Birngruber³

et al. 2017

RJLM

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Objectives. The consumption of drugs during pregnancy or delivery leads to pre and intranatal drug exposure of the fetus. The purpose of this study was to examine paired blood samples of the mother and the umbilical cord regarding drug distribution. Methods. Over a period of two years, 22 pregnant women with known or admitted drug use were selected. Paired blood samples of the mothers and the umbilical cord blood were collected shortly before and during birth/caesarean section, respectively. The samples were subjected to systematic immunochemical, HPLC-DAD, GC/MS and LC-MS/MS analysis and compared regarding presence of drugs. Results. Methadone, THC-COOH, tramadol, benzoylecgonine, citalopram, carbamazepine, lamotrigine, perazine, methylphenidate, quetiapine, ranitidine and most constituents of spinal and epidural anaesthesia were found in both, maternal and umbilical cord blood samples. THC, 11-OH-THC, olanzapine, diphenhydramine and telmisartan were found in maternal blood only. Conclusions. As previously shown a variety of drugs is able to pass the placenta of pregnant woman. Umbilical cord blood appears to be a viable matrix for the detection of maternal drug consumption. Drugs administered during labour and birth could be detected in umbilical cord blood. Further studies with a greater collective of women with known drug use including analyses of fetal/infant samples will yield additional information in the future.

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Section: Discussionsupporting

confidence: 70%