The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats

Fujimoto, Yohei; Kitaichi, Kiyoyuki; Nakayama, Haruhiko; Ito, Yukiko; Takagi, Kenji; Takagi, Kenzo; Hasegawa, Takaaki

doi:10.1538/expanim.56.119

Cited by 13 publications

(6 citation statements)

References 36 publications

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“…Although this was not a main research question from this study, this effect was observed here, specifically and exclusively in LER females. Strain differences in response to amphetamine have been observed previously 21 , 22 , 24 , 25 . This strain and sex specific effect in response to amphetamine may be the result of the interplay between the stress system and monoaminergic function, which has been posited to explain differences in response to amphetamine between two other strains of rats, Fisher 344 and Lewis 69 , 70 .…”

Section: Discussionsupporting

confidence: 60%

Adolescent THC exposure does not sensitize conditioned place preferences to subthreshold d-amphetamine in male and female rats

et al. 2018

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The acute effects of marijuana consumption on brain physiology and behaviour are well documented, but the long-term effects of its chronic use are less well known. Chronic marijuana use during adolescence is of increased interest, given that the majority of individuals first use marijuana during this developmental stage , and adolescent marijuana use is thought to increase the susceptibility to abusing other drugs when exposed later in life. It is possible that marijuana use during critical periods in adolescence could lead to increased sensitivity to other drugs of abuse later on. To test this, we chronically administered ∆ 9-tetrahydrocannabinol (THC) to male and female Long-Evans (LER) and Wistar (WR) rats directly after puberty onset. Rats matured to postnatal day 90 before being exposed to a conditioned place preference task (CPP). A subthreshold dose of d-amphetamine, found not to induce place preference in drug naïve rats, was used as the unconditioned stimulus. The effect of d-amphetamine on neural activity was inferred by quantifying cfos expression in the nucleus accumbens and dorsal hippocampus following CPP training. Chronic exposure to THC post-puberty had no potentiating effect on a subthreshold dose of d-amphetamine to induce CPP. No differences in cfos expression were observed. These results show that chronic exposure to THC during puberty did not increase sensitivity to a sub-threshold dose of d-amphetamine in adult LER and WR rats. This supports the concept that THC may not sensitize the response to all drugs of abuse.

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Section: Discussionsupporting

confidence: 60%

Adolescent THC exposure does not sensitize conditioned place preferences to subthreshold d-amphetamine in male and female rats

et al. 2018

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“…This was exclusively observed in LER females. Strain differences in response to amphetamine have been observed previously 19, 20, 22, 23 . This strain and sex specific effect in response to amphetamine may be the result of the interplay between the stress system and monoaminergic function, which has been posited to explain differences in response to amphetamine between two other strains of rats, Fisher 344 and Lewis 64, 65 .…”

Section: Discussionsupporting

confidence: 60%

Adolescent THC exposure does not sensitize conditioned place preferences to subthreshold d-amphetamine in male and female rats

et al. 2018

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The acute effects of marijuana consumption on brain physiology and behaviour are well documented, but the long-term effects of its chronic use are less well known. Chronic marijuana use during adolescence is of increased interest, given that the majority of individuals first use marijuana during this developmental stage , and adolescent marijuana use is thought to increase the susceptibility to abusing other drugs when exposed later in life. It is possible that marijuana use during critical periods in adolescence could lead to increased sensitivity to other drugs of abuse later on. To test this, we chronically administered ∆ 9-tetrahydrocannabinol (THC) to male and female Long-Evans (LER) and Wistar (WR) rats directly after puberty onset. Rats matured to postnatal day 90 before being exposed to a conditioned place preference task (CPP). A subthreshold dose of d-amphetamine, found not to induce place preference in drug naïve rats, was used as the unconditioned stimulus. The effect of d-amphetamine on neural activity was inferred by quantifying cfos expression in the nucleus accumbens and dorsal hippocampus following CPP training. Chronic exposure to THC post-puberty had no potentiating effect on a subthreshold dose of d-amphetamine to induce CPP. No differences in cfos expression were observed. These results show that chronic exposure to THC during puberty did not increase sensitivity to d-amphetamine in adult LER and WR rats. This supports the concept that THC may not sensitize the response to all drugs of abuse.

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“…Meth is rapidly absorbed from the peritoneum and then eliminated from the blood with a profile closely resembling a single-exponential process (23,76). Our data do not contain independent information about the volume of distribution.…”

Section: Model Constructionmentioning

confidence: 62%

Meth math: modeling temperature responses to methamphetamine

Molkov

Zaretskaia

Zaretsky

2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Methamphetamine (Meth) can evoke extreme hyperthermia, which correlates with neurotoxicity and death in laboratory animals and humans. The objective of this study was to uncover the mechanisms of a complex dose dependence of temperature responses to Meth by mathematical modeling of the neuronal circuitry. On the basis of previous studies, we composed an artificial neural network with the core comprising three sequentially connected nodes: excitatory, medullary, and sympathetic preganglionic neuronal (SPN). Meth directly stimulated the excitatory node, an inhibitory drive targeted the medullary node, and, in high doses, an additional excitatory drive affected the SPN node. All model parameters (weights of connections, sensitivities, and time constants) were subject to fitting experimental time series of temperature responses to 1, 3, 5, and 10 mg/kg Meth. Modeling suggested that the temperature response to the lowest dose of Meth, which caused an immediate and short hyperthermia, involves neuronal excitation at a supramedullary level. The delay in response after the intermediate doses of Meth is a result of neuronal inhibition at the medullary level. Finally, the rapid and robust increase in body temperature induced by the highest dose of Meth involves activation of high-dose excitatory drive. The impairment in the inhibitory mechanism can provoke a life-threatening temperature rise and makes it a plausible cause of fatal hyperthermia in Meth users. We expect that studying putative neuronal sites of Meth action and the neuromediators involved in a detailed model of this system may lead to more effective strategies for prevention and treatment of hyperthermia induced by amphetamine-like stimulants.

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The Pharmacokinetic Properties of Methamphetamine in Rats with Previous Repeated Exposure to Methamphetamine: The Differences between Long-Evans and Wistar Rats

Abstract: Repeated treatment with methamphetamine (METH) causes long-term behavioral changes, so-called behavioral sensitization (BS), in humans as

Cited by 13 publications

References 36 publications

Adolescent THC exposure does not sensitize conditioned place preferences to subthreshold d-amphetamine in male and female rats

Adolescent THC exposure does not sensitize conditioned place preferences to subthreshold d-amphetamine in male and female rats

Adolescent THC exposure does not sensitize conditioned place preferences to subthreshold d-amphetamine in male and female rats

Meth math: modeling temperature responses to methamphetamine

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