The pharmacokinetics and liver metabolism of N-hydroxy-3, 4-methylenedioxyamphetamine (NOH MDA) in rats

The metabolism and urinary excretion of N hydroxy 3,4 methylenedioxymethamphetamine (N OH MDMA), a newly banned narcotic in Japan, were explored to conˆrm biotransformation of N OH MDMA to 3,4 methylenedioxymethamphetamine (MDMA) and to discriminate between N OH MDMA and MDMA intake in forensic urine analysis. The in vitro and the in vivo experiences were performed with human liver S9 and rats, respectively, and the resultant products or metabolites were determined using liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry.In both the in vitro and the in vivo experiences, MDMA and 3,4 methylenedioxyamphetamine (MDA) were detected, and the MDA levels exceeded the MDMA levels throughout the entire periods except for during 3 h after administration to the rats. This suggests the existence of the metabolic pathway(s) from N OH MDMA to MDA not via MDMA. In urine samples from the administered rats parent N OH MDMA and its demethylated metabolite N hydroxy 3,4 methylenedioxyamphetamine (N OH MDA) with very low levels during short period after administration (6 h) were detected. The ratios of the urinary MDA/ MDMA levels for N OH MDMA administered rats were higher than those for MDMA administered rats. In addition, the determination of urinary diastereomers of glucuronidated 4 hydroxy 3 methoxymethamphetamine (HMMA), MDMA metabolite, revealed that the relative peak intensity of l HMMA glucuronide to d

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Comprehensive Analytical Procedures for the Unequivocal Determination of a Newly Encountered Drug “N-hydroxy-3,4-methylenedioxymethamphetamine (N-OH-MDMA)”

桂¹,

宗弘²,

啓子³

et al. 2010

Jpn. J. Forensic. Sci. Tech.

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The pharmacokinetics and liver metabolism of N-hydroxy-3, 4-methylenedioxyamphetamine (NOH MDA) in rats

Cited by 3 publications

References 7 publications

Determination of a new designer drug, N-hydroxy-3,4-methylenedioxymethamphetamine and its metabolites in rats using ultra-performance liquid chromatography–tandem mass spectrometry

Determination of a new designer drug, N-hydroxy-3,4-methylenedioxymethamphetamine and its metabolites in rats using ultra-performance liquid chromatography–tandem mass spectrometry

Metabolism and Urinary Excretion of N-Hydroxy-3,4-methylenedioxymethamphetamine, a Recently Banned Narcotic in Japan

Comprehensive Analytical Procedures for the Unequivocal Determination of a Newly Encountered Drug “N-hydroxy-3,4-methylenedioxymethamphetamine (N-OH-MDMA)”

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