1982
DOI: 10.1007/bf01065171
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The pharmacokinetics and pharmacodynamics of bumetanide in normal subjects

Abstract: The pharmacokinetics and pharmacodynamics of bumetanide (1 mg) administered either orally or intravenously were studied in a group of normal subjects using high-pressure liquid chromatography. A two-compartment model adequately fitted the intravenous data. Renal clearance (85 ml min-1) contributed 65% to the total elimination of bumetanide irrespective of whether a model-dependent or model-independent method was used. Oral administration of bumetanide elicited a greater and a more prolonged pharmacological res… Show more

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Cited by 28 publications
(21 citation statements)
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“…This paper describes the pharmacokinetics and pharmacodynamics of bumetanide when given orally and intravenously to a group of patients with chronic renal failure and to another group with cirrhosis of the liver. The results are compared with those previously obtained by us (Marcantonio et al, 1982) Hepatic group Eight patients aged from 54 to 76 years with chronic hepatic disease were included in this study. They all had cirrhosis of the liver (Table 2) which had been alcohol-induced in three cases.…”
Section: Introduction Methodsmentioning
confidence: 79%
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“…This paper describes the pharmacokinetics and pharmacodynamics of bumetanide when given orally and intravenously to a group of patients with chronic renal failure and to another group with cirrhosis of the liver. The results are compared with those previously obtained by us (Marcantonio et al, 1982) Hepatic group Eight patients aged from 54 to 76 years with chronic hepatic disease were included in this study. They all had cirrhosis of the liver (Table 2) which had been alcohol-induced in three cases.…”
Section: Introduction Methodsmentioning
confidence: 79%
“…There was little difference in the total amount of water, sodium, potassium and creatinine excreted in 24 h after oral and intravenous administration of bumetanide (Table 5) Marcantonio et al (1982) Xux = total amount of bumetanide excreted in urine in 30 h F = bioavailability *P < 0.05, ***P < 0.001 as compared with normal group was higher after oral than after intravenous administration (Table 5). This difference in response was statistically significant.…”
Section: Pharmacodynamicsmentioning
confidence: 98%
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