The pharmacokinetics, electrocardiographic effects, and tolerability of loratadine syrup in children aged 2 to 5 years

Levocetirizine: Pharmacokinetics and pharmacodynamics in children age 6 to 11 years

“…3 Most of the orally administered H 1 -antihistamines are available in dosage formulations suitable for administration to children and even to infants; however, only 11 of the 40 H 1 -antihistamines have been studied prospectively in children with regard to their pharmacokinetics and pharmacodynamics. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] These studies have generally been conducted after administration of a single dose, 5-10,12-20 but 3 studies have been performed at steady state, 11,12,20 and in a few studies, a population pharmacokinetic design [21][22][23] has been used. The clinical pharmacology of a few of the first-generation H 1 -antihistamines, such as chlorpheniramine, brompheniramine, diphenhydramine, and hydroxyzine, was investigated after they had been used in children for several decades.…”

Pediatric Allergic Rhinitis: Antihistamine Selection

“…The investigators reported that single and multiple doses were well tolerated, with no AE occurring with greater frequency after multiple doses of loratadine. 23 In addition, ECG parameters were comparable between loratadine and placebo, indicating cardiac safety, and there were no clinically meaningful changes in other tolerability assessments. 23 Cetirizine Cetirizine is available for the treatment of SAR in children as young 2 years, and is now indicated for the treatment of PAR in children aged ≥6 months.…”

A Comparative Study of Loratadine Syrup and Cyproheptadine HCL Solution for Treating Perennial Allergic Rhinitis in Taiwanese Children Aged 2–12 Years

“…Many second-generation H1-anti-histamines have approved dosing recommendations for children and are available in tablet form and as syrups or suspensions, which are convenient for use in young children and infants (18). Several trials have shown the safety and efficacy of the syrup formulations of cetirizine (19,20), levocetirizine (21), loratadine (22), and desloratadine (23,24) in children with allergic rhinitis. These second-generation H]-anti-histamine syrups are effective against histamine-mediated symptoms, such as rhinorrhea, sneezing, nasal itching, nasal congestion, and ocular symptoms (20,22,24), and once-daily use provides better tolerance and compliance.…”

“…Several studies have considered the efficacy and safety of loratadine for treating allergic rhinitis (8,25). Similarly, our randomized, active-controlled study shows that once daily loratadine syrup, 5 or 10 mg, is effective for and well-tolerated by Taiwanese children aged 2-12 years with allergic rhinitis.…”