The Pharmacokinetics of Fluoride in Mouth Rinses as Indicated by a Reference Substance (⁵¹Cr-EDTA)

Abstract

Mouth rinses with 7 ml 0.05% NaF containing ⁵¹Cr-EDTA (2 μCi) were performed by 11 dental staff members. The water-soluble non-absorbable ⁵¹Cr-EDTA was added to enable estimations of the amount of fluid swallowed and the quantity of fluoride retained and/or absorbed in the oral cavity. Experiment 1. 2-min rinses with 7 ml test solution were followed by three 1-min rinses with 10 ml water. The recoveries of ⁵¹Cr-EDTA and fluoride in the first expectorate were 86.3 ± 4.0% and 83.9 ± 4.1% (n = 11), respectively. After the succeeding water rinses, a difference of 1.8 ± 0.9% remained, which represents the fraction of fluoride being absorbed from and/or retained more firmly in the oral cavity. The amount of ⁵¹Cr-EDTA not recovered from the expectorates after this rinsing procedure (5.3 ± 3.0%) indicates the fraction of the test solution swallowed. Experiment 2. This was similar to experiment 1, except that the rinsing with test solution lasted only 30 sec. No significant difference in the total recoveries was observed (0.0 ± 1.0%), and only 1.7 ± 1.6% was estimated to have been swallowed. The findings indicate that (1) negligible parts of the retained fluoride is absorbed from the oral cavity, (2) 2-min vs. 30-sec rinsing periods increased the fraction of fluid swallowed, (3) after 2-min rinses, in contrast to 30-sec rinses, the oral cavity retained a significant fraction of fluoride not removable by the water rinses.

The oral clearance of zinc and triclosan after delivery from a dentifrice

“…These figures are derived by subtraction and therefore take no account of the loss that may have occurred due to inadvertent swallowing. This loss has previously been estimated by Birkeland & Lokken (1972), using model systems, to be ca 5% of the original dose.…”

Post-brushing rinsing for the control of dental caries: exploration of the available evidence to establish what advice we should give our patients

“…Fluoride concentration 3,[32][33][34] Fluoride compound -NaF, Na 2 FPO 3 , SnF 2 , amine F [35][36] Mouth rinse pH 37 Rinsing volume 7,38 Rinsing time 16,38 Rinsing frequency -once daily, twice daily, weekly, or every two weeks [39][40] Timing of fluoride mouth rinse use: 7,[41][42][43] Before or after meals Morning versus bedtime After fluoride dentifrice use Oral physiology: 3,17,41,44 Salivary flow rate Oral architecture Prior dental plaque removal 45 Post-fluoride mouth rinsing behaviour: Eating and drinking Talking NaF (226 ppm F), and 0.02% NaF (100 ppm F). Products may be acidulated or neutral.…”

A Critique of Topical Fluoride Methods (Dentifrices, Mouthrinses, Operator‐, and Self‐applied Gels) in an Era of Decreased Caries and Increased Fluorosis Prevalence

“…Some fluoride mouthrinse solution will be retained and, presumably, swallowed (40,(122)(123)(124)(125)(126)(127). Although there is large interand intraindividual variation in the amount of solution retained (1241, four factors that influence retention are: age (the younger the rinser, the more solution tends to be retained) (40,122,124); rinsing time (longer periods produce more retention) (122,123); volume (the more solution used for rinsing, the more retained) (122,124); and previous experience with the rinsing procedure (the less experienced rinser retains more) (122). Wei and Kanellis (122) evaluated the retention of fluoride when preschool children rinsed with different volumes of solution and rinsing times.…”