The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis

Sunyecz, John A; Wiesenfeld, Harold C.; Heine, R. Phillips

doi:10.1002/(sici)1098-0997(1998)6:4<160::aid-idog4>3.0.co;2-c

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our report in this issue of the journal, we evaluated the pharmacokinetics of once-daily gentamicin in women with postpartum endometritis. 14 Using a single daily dose of 4.5 mg/kg actual body weight, peak gentamicin levels were above 10 mg/L, with consistently low trough levels. Clinical efficacy of…”

Section: Once-daily Gentamicin Wiesenfeld and Heinementioning

confidence: 99%

See 1 more Smart Citation

The Use of Once‐Daily Dosing of Gentamicin inObstetrics and Gynecology

Wiesenfeld

Heine

1998

Infectious Diseases in Obstetrics and Gynecology

View full text Add to dashboard Cite

Gentamicin is a widely-used antimicrobial agent for obstetric and gynecologic infections. Renewed excitement in this antibiotic has arisen from recent information supporting less frequent dosing. In this symposium, we will describe the pharmacokinetics of gentamicin and review new information advocating the use of once-daily administration of gentamicin. Infect. Dis. Obstet. Gynecol. 6:155-159, 1998. (C) 1998 Wiley-Liss, Inc. KEY WORDSgentamicin; antimicrobials; gynecologic infection minoglycosides, discovered over half a century ago, remain among the most frequently prescribed antibiotic agents for serious infections. Aminoglycosides are an important component of the obstetrician-gynecologist's armamentarium for obstetrical, gynecological, and postoperative infections. Gentamicin is the most widely used aminoglycoside in these settings, and thus will be the focus of this paper. While aminoglycosides have been in use for several decades, recent information supporting the administration of these agents once a day has brought renewed interest in this "older" class of compounds for this modern, cost-conscience medical era. STRUCTURE AND DERIVATIONGentamicin is a fermentation product derived from the soil actinomycetes Micromonospora purpurea and Micromonospora echinospora. All aminoglycosides are comprised of an essential six-membered ring with amino-group constituents bound to at least two sugar moieties. Gentamicin is soluble in water but insoluble in organic solvents, thereby restricting permeability across the lipid-rich cell membranes. MECHANISM OF ACTION SUMMARYGentamicin remains a widely used antibiotic for treating obstetric and gynecologic infections because of its activity against gram-negative organ-

show abstract

Section: Once-daily Gentamicin Wiesenfeld and Heinementioning

confidence: 99%

“…We calculated a 44% reduction in patient charges with once-daily dosing of gentamicin for 72 hours of therapy. 14…”

Section: Costmentioning

confidence: 99%

The Use of Once‐Daily Dosing of Gentamicin inObstetrics and Gynecology

Wiesenfeld

Heine

1998

Infectious Diseases in Obstetrics and Gynecology

View full text Add to dashboard Cite

show abstract

The use of once-daily dosing of gentamicin in obstetrics and gynecology

Wiesenfeld

Heine

1998

Infect. Dis. Obstet. Gynecol.

Self Cite

View full text Add to dashboard Cite

Gentamicin is a widely‐used antimicrobial agent for obstetric and gynecologic infections. Renewed excitement in this antibiotic has arisen from recent information supporting less frequent dosing. In this symposium, we will describe the pharmacokinetics of gentamicin and review new information advocating the use of once‐daily administration of gentamicin. Infect. Dis. Obstet. Gynecol. 6:155–159, 1998. © 1998 Wiley‐Liss, Inc.

show abstract

Single daily dosing of gentamicin: Pharmacokinetic comparison of two dosing methodologies for postpartum endometritis

Liu

Abate

Reyes

et al. 1999

Infect. Dis. Obstet. Gynecol.

View full text Add to dashboard Cite

OBJECTIVE: We compared the pharmacokinetics of two methods for dosing gentamicin for the treatment of postpartum endometritis with the goal of achieving adequate peak serum concentrations (>12 mg/L) and prolonged trough levels below 2 mg/L. METHODS: Group-I subjects (n = 5) received intravenous gentamicin, 5 mg/kg per total body weight over 60 min., with a maximum dose of 500 mg. Group-II subjects (n = 17) were dosed intravenously according to the following formula: Dose = desired peak concentration (fixed at 14 mg/L) * (volume of distribution, i.e., 0.35 L/kg) * adjusted body weight (in kilograms). Serum gentamicin levels were obtained 1 hr. and 8-12 hr. after infusion of the second dose. Pharmacokinetic parameters for the subjects in each group were calculated according to standard formulas. RESULTS: Subjects in Group I had significantly higher doses and peak drug concentrations (P < 0.01), while in Group II, 76% of patients had peak levels less than desired (<12 mg/L). Both groups maintained trough levels of <2 mg/L in excess of 12 hr. CONCLUSIONS: Changing to the adjusted body weight formula for Group I, while maintaining a dose between 4 and 5 mg/kg, would reduce excessive peak concentrations. Using a calculated volume of distribution of 0.4 L/kg in Group II would improve peak serum concentrations to the desired levels. Both dosing regimens ensure adequate aminoglycoside pharmacokinetic parameters and avoid the need for monitoring serial serum drug concentrations, provided the expected clinical response is also achieved. While the first dosing formula is simpler to calculate, the second dosing formula allows for more individualized dosing considerations.

show abstract

The pharmacokinetics of once-daily dosing with gentamicin in women with postpartum endometritis

Cited by 4 publications

References 7 publications

The Use of Once‐Daily Dosing of Gentamicin inObstetrics and Gynecology

The Use of Once‐Daily Dosing of Gentamicin inObstetrics and Gynecology

The use of once-daily dosing of gentamicin in obstetrics and gynecology

Single daily dosing of gentamicin: Pharmacokinetic comparison of two dosing methodologies for postpartum endometritis

Contact Info

Product

Resources

About