1987
DOI: 10.3109/03009748709096719
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The Pharmacokinetics of Sulphasalazine in Young and Elderly Patients with Rheumatoid Arthritis

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1987
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Cited by 19 publications
(5 citation statements)
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“…Trials that had compared individual daily doses of 2 and 3 g SSZ reported that the therapeutic efficacy was comparable [73]. Age as well as the acetylator status influences the achievement of a steady state of drug concentration [74,75]. The mechanism by which the SSZ is effective in RA is explained by its pleiotropic effect on different limbs of immune system like T-cell, synoviocytes and adenosine pathway (Tables 1 and 2) [76][77][78].…”
Section: Hydroxychloroquinementioning
confidence: 99%
“…Trials that had compared individual daily doses of 2 and 3 g SSZ reported that the therapeutic efficacy was comparable [73]. Age as well as the acetylator status influences the achievement of a steady state of drug concentration [74,75]. The mechanism by which the SSZ is effective in RA is explained by its pleiotropic effect on different limbs of immune system like T-cell, synoviocytes and adenosine pathway (Tables 1 and 2) [76][77][78].…”
Section: Hydroxychloroquinementioning
confidence: 99%
“…The pharmacokinetic studies of SSZ in elderly RA patients have shown that the acetylator phenotype, but not age, plays a role in determining the serum concentration of sulfapyridine. 17 SSZ is likely to be as effective as lower doses of MTX, although it is usually no longer recommended as monotherapy for RA. 18 In a randomized controlled study, published in 1983, elderly patients were found to have a higher dropout rate due to the occurrence of nausea and vomiting than younger patients.…”
Section: Sulfasalazinementioning
confidence: 99%
“…gegenüber, nach dem das SASP im Plasma nur in 82,4 % und in der Synovia nur in 88,2% nachgewiesen werden konnte (1). Die SASP-und freies SP-Konzentrationen entsprachen den durch andere Untersucher bei Colitis ulcerosa (3,4,8) und bei c. P. (2,11,19,24) gemessenen Werten. Über den 5-ASA-Spiegel der Synovialflüssigkeit erschien bisher -unseres Wissens nach -noch keine Publikation.…”
Section: Diskussionunclassified
“…Im Laufe der SASP-Behandlung liegt der freie SP-Spiegel im Serum bei Langsamazetylierern signifikant höher, wie dies -in Übereinstimmung mit unseren Messungen -bei Patienten mit chronischer Darmerkrankung (3, 4, 8) und C.P. (2,19,24) durchgeführten Untersuchungen gleicherweise nachgewiesen wurde.…”
Section: Diskussionunclassified
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