The Pharmacologic Action of 2,2 Bis(P-Chlorophenyl) 1,1,1 Trichlorethane and Its Estimation in the Tissues and Body Fluids

Evaluation of County-Wide DDT Dusting Operations in Murine Typhus Control

“…Field observations and rat coloiiy experience indicated that toxic effects, similar to those seen in laboratory experiments on rats, occurred following DDT dusting operations (8). Although there was no way of knowing the degree of rat morta.lity occasioned by county-wide DDT dusting operations, some rat deaths were attributable to this cause.…”

Toxic Effects of D.D.T. in Man

“…D.D.T. has been shown to be toxic to a variety of mammals, including rabbits, guinea-pigs, rats (Draize, Nelson, and Calvery, 1944;Smith and Stohlman, 1944;Cameron and Burgess, 1945), cows, sheep, horses (Draize et al, 1944), and cats (Lillie and Smith, 1944). The main pathological features seem to be liver damage of varying degree sometimes reaching the stage of necrosis, loss of weight, anorexia, mild anaemia with a reduction of the mean corpuscular haemoglobin, polymorphonuclear leucocytosis, and damage to the central nervous system, causing excitability, instability, tremors, and muscular weakness (Cameron and Burgess, 1945).…”

“…The main pathological features seem to be liver damage of varying degree sometimes reaching the stage of necrosis, loss of weight, anorexia, mild anaemia with a reduction of the mean corpuscular haemoglobin, polymorphonuclear leucocytosis, and damage to the central nervous system, causing excitability, instability, tremors, and muscular weakness (Cameron and Burgess, 1945). No specific histological changes have been reported in the C.N.S., though various authors have noted some degeneration, vacuolation, pyknosis, and tigrolysis of a few anterior horn cells in the thoracic and lumbar regions (Cameron and Burgess, 1945;Lillie and Smith, 1944;Smith and Stohlman, 1944).…”

Fatal D.D.T. Poisoning

“…body-weight. Smith and Stohlman (1944) gave a 1 to 5% solution of D.D.T. in olive oil by stomach tube to rats and rabbits, and assessed the L.D.…”