The pharmacological activity of berberine, a review for liver protection

Zhou, Mengting; Deng, Ying; Liu, Meichen; Liao, Li; Dai, Xuyang; Guo, Chaocheng; Zhao, Xingtao; He, Linfeng; Peng, Cheng; Li, Yunxia

doi:10.1016/j.ejphar.2020.173655

Cited by 70 publications

(56 citation statements)

References 149 publications

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“…Male BALB/c mice Sprague-Dawley rat fetal cortical neurons 0.5, 1, 2, and 5 mg/kg a single i.p. dose 10 −8 mol/L 0.5, 1, or 2 days Anti-nociceptive effects "opioid receptors expression in mouse intestine " μ and δ opioid receptor expression and Chen, Tao, et al (2015) Male Sprague-Dawley rat 50 mg/kg Visceral anti-nociceptive effects NO synthase inhibition diminished the effects of BER , 2020;Kuner, 2010;Liu-Bryan, 2013). In this regard, antiinflammatory effects of BER were assessed in vitro; treatment of oral cancer cell lines OC2 and KB with BER resulted in lower expression of COX-2 and prostaglandin E2 (PGE2) but did not affect their activities (Kuo, Chi, & Liu, 2004).…”

Section: Miscellaneousmentioning

confidence: 99%

“…Moreover, BER has shown various beneficial medicinal properties including anti-tumour, anti-hypertensive, anti-hyperlipidemic, cardioprotective, neuroprotective, anti-arthritic, antiinflammatory and anti-oxidant effects that could help in the treatment of diabetes, obesity and inflammation Chen, Tao, et al, 2015;Kim & Kim, 2013;Yang et al, 2020;Zhou, Yan, Guo, & Tong, 2019). Most of such pharmacological effects of BER were attributed to its anti-oxidant and antiinflammatory properties, as well as its modulatory effects on a spectrum of enzymes, receptors and cell signalling pathways (Habtemariam, 2020). Clinically, the effects on BER-in combination with standard treatments-against Helicobacter pylori were assessed, and a meta-analysis showed that the beneficial effects of BER in this regard were accompanied by lower adverse effects (Hu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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A review on pain‐relieving activity of berberine

Hashemzaei

Rezaee

2020

Phytotherapy Research

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As isoquinoline alkaloid naturally occurs in Coptis and Berberis species, berberine (BER) has shown anti‐oxidant, anti‐tumour, anti‐bacterial and hepatoprotective activities and beneficial effects against digestive, cardiovascular and neurological conditions. Also, BER antiinflammatory, pain‐relieving and anti‐cholinesterase activities were widely studied. The present overview discusses the analgesic effects of BER. Based on the literature, BER exerted pain‐relieving activity against diabetic and chemotherapy‐induced neuropathy, and sciatic nerve injury‐induced pain via down‐regulation of transient receptor potential vanilloid 1, suppression of NF‐κB and modulation of μ and δ opioid receptors. Besides, BER could repress inflammatory markers tumour necrosis factor‐α, interleukin‐6 and IL‐1β, as well as prostaglandin E2, inducible nitric oxide synthase and cyclooxygenase‐2. The modulatory effects of BER on dopamine and N‐methyl d‐aspartate systems were also noted. Moreover, BER could induce Nrf2 expression but inhibits p38‐MAPK and STAT3 phosphorylation. Noteworthy, anti‐cholinesterase activity, which may potentially contribute to BER analgesic properties, warrants particular attention.

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Section: Miscellaneousmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A review on pain‐relieving activity of berberine

Hashemzaei

Rezaee

2020

Phytotherapy Research

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“…The berberine (BBR) is an isoquinoline alkaloid mainly derived from Coptis chinesis with great therapeutic impacts [ 375 ]. In addition, BBR can be isolated from other Berberis plants such as Berberis julianae and Scutellaria baicalensis [ 376 ]. Although BBR has pharmacological activities including antioxidant, anti-inflammatory, anti-diabetes, hepatoprotective and renoproective, among others, much attention has been directed towards its anti-tumor activities [ 377 , 378 , 379 , 380 ].…”

Section: Dietary Agents and Cancer Stem Cellsmentioning

confidence: 99%

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Paskeh

Asadi²,

Zabolian

et al. 2021

IJMS

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As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use.

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“…Unter dem Aspekt, dass Berberin hepatoprotektive Effekte [19] [20] besitzt und Statine hepatotoxisch sind, eröffnen sich interessante Synergieeffekte von Statinen mit Berberin. In-vivo-Studien an Hamstern konnten den Berberin-Effekt auf den LdL-Spiegel belegen.…”

Section: Berberin Und Die Blutlipideunclassified

Berberin bei Atherosklerose – Verbesserung des Lipidprofils der Endothelfunktion

Bielenberg¹

2021

Erfahrungsheilkunde

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ZusammenfassungAtherosklerose ist eine multifaktorelle Gefäßerkrankung, verursacht durch Fettstoffwechselstörungen, chronische Entzündungsprozesse des Gefäßendothels, Plaquebildung mit Stenosen und thrombotischen Prozessen, induziert durch Plaquerupturen. In letzter Zeit verdichten sich mehr und mehr Erkenntnisse über die therapeutische Wirkung von Berberin bei Atherosklerose: Verbesserung der mitochondrialen Funktion, Verhinderung von Oxidationsprozessen im Gefäßendothel sowie entzündungshemmende Wirkungen. Darüber hinaus ergeben sich neue Erkenntnisse hinsichtlich antiatherogener Effekte durch eine Induktion der Autophagie und einer Reduktion des PCSK9-Spiegels. Der folgende Artikel stellt einen neuen Kandidaten für den Schutz vor Atherosklerose durch Verbesserung des Lipidprofils und der Endothelfunktion der Koronargefäße vor.

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The pharmacological activity of berberine, a review for liver protection

Cited by 70 publications

References 149 publications

A review on pain‐relieving activity of berberine

A review on pain‐relieving activity of berberine

Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies

Berberin bei Atherosklerose – Verbesserung des Lipidprofils der Endothelfunktion

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