The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey

İnanir, Merve; Uçar, Esra; Tüzün, Burak; Eruygur, Nuraniye; Ataş, Mehmet; Akpulat, Hüseyin Aşkın

doi:10.1016/j.ijbiomac.2024.130943

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.130943

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The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey

Merve İnanir,

Esra Uçar,

Burak Tüzün

et al.

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Cited by 5 publications

References 43 publications

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Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Kaymak,

Kurtur,

Gok

et al. 2024

Phytochemical Analysis

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IntroductionOsteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low‐toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic.ObjectiveIn this study, we aim to prepare a controlled drug carrier system loaded with Gypsophila eriocalyx to determine its potential for anti‐osteoporosis applications.MethodsGypsophila eriocalyx extract (GEE) was prepared, and components were determined. The molecular interactions of the components with Cathepsin K (CatK), which is used as a target in drug development against osteoporosis, were revealed by in silico molecular docking and MD methods. ADMET profiles were also examined. GEE‐loaded chitosan nanoparticles (CNPs) were synthesized. The nanoparticles' morphology, encapsulation efficiency, loading capacity, release profile, average size, polydispersity index, and zeta potentials were determined. The cytotoxic effects of GEE and GEE‐loaded CNPs on the L929 and osteogenic proliferation profiles on human bone marrow stem cells (hBMC) were examined.ResultsThe MD analysis revealed no breaks or atomic changes in the dynamic system, and the docking analysis confirmed the continued interaction of identical residues. It was determined that the GEE‐loaded CNP formulation was produced successfully, had no toxic effect on the L929, and had an osteogenic proliferation effect on hBMC.ConclusionIn line with the in vitro and in silico results obtained, it was evaluated that GEE‐loaded CNPs can be used as a controlled drug release system as a candidate formulation with phytotherapeutic properties for osteoporosis treatment.q1

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Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Kaymak,

Kurtur,

Gok

et al. 2024

Phytochemical Analysis

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show abstract

Molecular descriptors and in silico studies of 4-((5-(decylthio)-4-methyl-4n-1,2,4-triazol-3-yl)methyl)morpholine as a potential drug for the treatment of fungal pathologies

Myroslava,

Poustforoosh,

Inna

et al. 2024

Computational Biology and Chemistry

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A study on insecticidal activity of the fennel (Foeniculum vulgare) essential oil and its nanoemulsion against stored product pests and molecular docking evaluation

Çi̇çek,

Korkmaz,

Tüzün

et al. 2024

Industrial Crops and Products

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The pharmacological properties of Gypsophila eriocalyx: The endemic medicinal plant of northern central Turkey

Cited by 5 publications

References 43 publications

Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

Molecular descriptors and in silico studies of 4-((5-(decylthio)-4-methyl-4n-1,2,4-triazol-3-yl)methyl)morpholine as a potential drug for the treatment of fungal pathologies

A study on insecticidal activity of the fennel (Foeniculum vulgare) essential oil and its nanoemulsion against stored product pests and molecular docking evaluation

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