2024
DOI: 10.2174/1570159x21666230804110858
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The Pharmacological Treatment of Neuropathic Pain in Children

Abstract: The International Association for the Study of Pain (IASP) defines neuropathic pain as pain caused by a lesion or disease of the somatosensory nervous system. It is characterized as a clinical condition in which diagnostic studies reveal an underlying cause of an abnormality in the peripheral or central nervous system. Many common causes of neuropathic pain in adults are rare in children. The purpose of this focused narrative review is, to 1) provide an overview of neuropathic pain in children, 2) highlight un… Show more

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“…107 Recent studies suggested that personalized treatment approaches to various pediatric chronic pain conditions in general, and in pediatric neuropathic pain in particular, can be developed based on the individual nociceptive phenotypes as determined by the use of Quantitative Sensory Testing and conditioned pain modulation evaluation (QST/CPM). [108][109][110] QST/CPM testing appears to provide more targeted therapeutic options, resulting in less polypharmacotherapy and the use of interventional treatments, while still being at least as effective as standard treatment protocols. However, further studies are needed to examine the potential benefits of pain phenotyping and to confirm these hypotheses.…”
Section: Brief Summary Of Pharmacologic and Non-pharmacologic Treatme...mentioning
confidence: 99%
“…107 Recent studies suggested that personalized treatment approaches to various pediatric chronic pain conditions in general, and in pediatric neuropathic pain in particular, can be developed based on the individual nociceptive phenotypes as determined by the use of Quantitative Sensory Testing and conditioned pain modulation evaluation (QST/CPM). [108][109][110] QST/CPM testing appears to provide more targeted therapeutic options, resulting in less polypharmacotherapy and the use of interventional treatments, while still being at least as effective as standard treatment protocols. However, further studies are needed to examine the potential benefits of pain phenotyping and to confirm these hypotheses.…”
Section: Brief Summary Of Pharmacologic and Non-pharmacologic Treatme...mentioning
confidence: 99%