The Pharmacology and Therapeutic Aspects of Colchicine

Hello, C. Le

doi:10.1016/s1099-4831(08)60063-2

Cited by 9 publications

(9 citation statements)

References 311 publications

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“…Colchicine has been found to possess antitumoral and antiinflammatory properties and has still kept its importance in the treatment of gout and many other diseases, such as familial Mediterranean fever (FMF), Behçet's syndrome, chirosis, and psoriasis (Le Hello, 2000). Unfortunately, due to its low therapeutic index, this alkaloid cannot be used as an antineoplastic agent.…”

Section: Introductionmentioning

confidence: 99%

“…It is also used in biological and breeding studies to produce polyploids and in the tubulin binding assay as a positive control because of its affinity for tubulin (Al-Fayyad et al, 2002;Evans, 2002). Demecolcine has lower toxicity than colchicine and has been successfully used in treatment, especially for myeloid leukemia and Hodgkin's syndrome (Le Hello, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

Pırıldar

Sütlüpınar

Atasever

et al. 2009

Pharmaceutical Biology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

Pırıldar

Sütlüpınar

Atasever

et al. 2009

Pharmaceutical Biology

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“…It is also used in biological and breeding studies to produce polyploids and in the tubulin binding assay as a positive control because of its affinity for tubulin [3]. Demecolcine has lower toxicity than colchicine and has been succefully used in the treatment, especially, of myeloid leukemia and Hodgkincs syndrome [2].The genus Colchicum (Colchicaceae) is represented by 45 species in Turkey. Turkey is a major center for diversity and speciation for Colchicum species when the endemism rate (35%) is considered [4,5].…”

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confidence: 99%

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confidence: 99%

Colchicinoids from the Seeds of Colchicum umbrosum

2015

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A new colchicinoid from the seeds of Colchicum umbrosum (Colchicaceae) has been isolated and identified as 4-hydroxycolchicine (6) together with seven known colchicinoids as colchicine (1), N-deacetyl-Nformylcolchicine (2), colchifoline (3), colchicilline (4), 3-demethylcolchicine (5), demecolcine (7), and colchicoside (8).The medicinal importance of the genus Colchicum is attributed to the presence of tropolonic alkaloids, colchicinoids, mainly colchicine [1]. Colchicine has been found to possess antitumoral and anti-inflammatory properties and has still kept its importance in the treatment of gout and many other diseases, such as familial Mediterranean fever (FMF), Behcetcs syndrome, chirosis, and psoriasis [2]. Unfortunately, due to its low therapeutic index, this alkaloid cannot be used as an antineoplastic agent. It is also used in biological and breeding studies to produce polyploids and in the tubulin binding assay as a positive control because of its affinity for tubulin [3]. Demecolcine has lower toxicity than colchicine and has been succefully used in the treatment, especially, of myeloid leukemia and Hodgkincs syndrome [2].The genus Colchicum (Colchicaceae) is represented by 45 species in Turkey. Turkey is a major center for diversity and speciation for Colchicum species when the endemism rate (35%) is considered [4,5].In continuation of our investigations on Turkish Colchicum species for their alkaloid content [6-9], we now study alkaloids from the seeds of Colchicum umbrosum. This is the first detailed investigation of the seeds of Colchicum umbrosum for their colchicinoids. In a previous work, it has been reported that the corms of this plant contain colchicine, 3-demethylcolchicine, N-formyl-N-deacetylcolchicine, colchifoline, and colchicoside as colchicinoids [10].We now report the presence of a new colchicinoid, 4-hydroxycolchicine, isolated fort he first time from a natural source (6), together with the known colchicinoids colchicine (1), N-deacetyl-N-formylcolchicine (2), colchifoline (3), colchicilline (4), 3-demethylcolchicine (5), demecolcine (7), and colchicoside (8) in the seeds of Colchicum umbrosum.

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“…The most important are colchicine, used against gout, and colchicoside, which, transformed into thiocolchicoside, possesses myorelaxant properties (Gaignault 1981;Le Hello 1996). Other numerous uses of these alkaloids: familial Mediterranean fever, liver fibrosis and cirrhosis are in the course of development (Ben-Chetrit and Levy 1998;Rambaldi and Gluud 2000;Simkin and Gardner 2000).…”

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Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation

Girardin¹

2003

Can. J. Plant Sci.

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Poutaraud, A. and Girardin, P. 2003. Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation. Can. J. Plant Sci. 83: 23-29. Alkaloids extracted from meadow saffron seeds are used in numerous medicines. To test the influence of cultivation and climatic conditions on the production and the quality of meadow saffron seeds, we studied seed alkaloid yield on a natural site (grassland) and in a cultivated crop over several years. Seeds contained in capsules harvested before their dehiscence were dried and ground. The alkaloids of the extracts (colchicoside, demethylcolchicine and colchicine) were analyzed by high-pressure liquid chromatography. Seed alkaloid content was not influenced by year, inter-plant competition, or number of capsules per plant. Seed dry matter yield per plant, however, practically tripled in the cultivated crop due to an increase in the number of capsules per plant compared to the grassland. In the cultivated crop, 47% of fruiting plants produced two new plants (corms) every year. Four years after planting, this vegetative multiplication resulted in intraspecific competition, inducing a decline in seed yield per plant linked to a decrease in the weight of seeds per capsule. We were able to show that cultivated production of meadow saffron greatly increased dry matter and alkaloid yield per plant and per hectare, but that it could lead to the need to thin after several years. Les alcaloïdes extraits des graines de colchiques entrent dans la composition de nombreux médicaments. Afin de tester l'influence de la mise en culture et des conditions climatiques sur la production de graines de colchique, nous avons étudié les composantes du rendement en alcaloïdes en prairie et en culture durant plusieurs années. Les graines contenues dans les capsules récoltées avant leur déhiscence ont été séchées, broyées. Les alcaloïdes extraits ont été analysés en chromatographie en phase liquide. Les teneurs en alcaloïdes n'ont été influencées ni par l'année de culture, ni par la concurrence entre plantes (inter ou intraspécifique), ni par le nombre de capsules par plante. Par contre, le rendement en graines sèches par plante a pratiquement triplé à cause de la levée de la concurrence interspécifique (prairie), essentiellement du fait d'une augmentation du nombre de capsules par plante. En culture, 47 % des plantes fructifères se sont dédoublées chaque année. A partir de la 4 ème année de culture, cette multiplication a entraîné une concurrence intraspécifique provoquant une baisse de rendement en graines par plante liée essentiellement à une diminution du poids de graines par capsule. Ainsi, nous avons pu montrer que la mise en culture des colchiques augmentait de façon importante le rendement en matière sèche par plante et par hectare mais pouvait nécessiter un démariage après plusieurs années.

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The Pharmacology and Therapeutic Aspects of Colchicine

Cited by 9 publications

References 311 publications

Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

Chemical constituents of the different parts ofColchicum baytopiorumand their cytotoxic activities on K562 and HL60 cell lines

Colchicinoids from the Seeds of Colchicum umbrosum

Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation

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