1987
DOI: 10.1111/j.1749-6632.1987.tb45802.x
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The Pharmacology of Monoclonal Antibodiesa

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Cited by 105 publications
(52 citation statements)
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“…Amount of leakage also depends on vascular surface area, endothelial permeability, driving force for extravasation, and interstitial fluid pressure (9)(10)(11)(12). Dose, plasma kinetics, specific binding to targets, metabolism, extracellular matrix composition, and lymphatic outflow are additional factors that influence movement of extravasated antibodies in tumors (14,15,43). The effect of high affinity binding of antibodies to tumor cell antigens (''binding site barrier'') on antibody movement in tumors has been shown by using mathematical models (44,45).…”
Section: Discussionmentioning
confidence: 99%
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“…Amount of leakage also depends on vascular surface area, endothelial permeability, driving force for extravasation, and interstitial fluid pressure (9)(10)(11)(12). Dose, plasma kinetics, specific binding to targets, metabolism, extracellular matrix composition, and lymphatic outflow are additional factors that influence movement of extravasated antibodies in tumors (14,15,43). The effect of high affinity binding of antibodies to tumor cell antigens (''binding site barrier'') on antibody movement in tumors has been shown by using mathematical models (44,45).…”
Section: Discussionmentioning
confidence: 99%
“…High interstitial pressure is thought to result from tumor vessel leakiness coupled with impaired fluid clearance due to the absence of functional intratumoral lymphatics and possibly contractile elements in stroma (10,13). Binding to targets also slows antibody transport in tumors (14,15). Nonuniformity of tumor vessel leakiness (16)(17)(18) imparts additional heterogeneity of antibody access to tumor cells (13).…”
Section: Introductionmentioning
confidence: 99%
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“…to detect or treat a solid tumor, they generally distribute nonuniformly in the mass (1)(2)(3)(4)(5)(6)(7)(8). A number of possible reasons, reflecting the heterogeneity seen in almost all characteristics of cancer (9)(10)(11), have been suggested: heterogeneous antigen (Ag) expression within the tumor; heterogeneous blood supply; elevated interstitial pressure; and mechanical barrierse.g., tight junctions between cells (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”
mentioning
confidence: 99%
“…Unfortunately, such approaches have not become widely adopted as most quantitative measurements of concentration are still measured and interpreted merely in terms of plasma concentrations and total tissue uptake (11,12). This mini-review summarizes a…”
mentioning
confidence: 99%