The pharmacology of ornipressin (POR-8): a local vasoconstrictor used in surgery

Theoretical comparison of molecular properties of linear and cyclic glycine derived peptides and their phosphor analogues

“…The cyclic compounds, like some hormones [7][8][9][10][11], immunosuppressants [12], or some antibiotics: macrolides [13], peptides [14], ansamycine [15], polyene [16] and antineoplastic agents are large and important group of compounds in medicinal chemistry for their pharmacological activity [17]. In many cases cyclic compounds are known to have much better biological properties when compare to their linear equivalents [18].…”

Local Anesthesia in Hair Transplantation

“…ST depression was found in a 19-year-old who had 0.8 IU of ornipressin injected into peritonsillar tissues. 27 Studies of cardiac effects in guinea pigs found coronary vasoconstriction, leading to decreased coronary blood flow and increased oxygen extraction. 28 Ornipressin can also cause elevation of blood pressure and affect heart rates.…”

“…28 Ornipressin can also cause elevation of blood pressure and affect heart rates. 27,29 Thus ornipressin must be used with caution in patients with hypertension or coronary artery disease.…”

A DFT study on the kinetics and mechanism of cyclodiglycine thermal decomposition in the gas phase

“…The topological structures of unusual carbon and nucleic acid compounds are widely described in the literature [7][8][9][10][11][12]. Cyclic structures may be found in antibiotics, hormones, immunosuppressants, macrolides, peptides and antineoplastic agents, which are large and important groups of compounds in medicinal chemistry [13][14][15][16][17][18][19][20][21][22]. In many cases, cyclic compounds are known to have much better biological properties in comparison to their linear equivalents [23,24].…”