The Phenomenon of Antiretroviral Drug Resistance in the Context of Human Immunodeficiency Virus Treatment: Dynamic and Ever Evolving Subject Matter

Apetroaei, Miruna-Maria; Velescu, Bruno Ștefan; Nedea, Marina Ionela (Ilie); Dinu-Pîrvu, Cristina Elena; Drăgănescu, Doina; Fâcă, Anca Ionela; Udeanu, Denisa Ioana; Arsene, Andreea Letiția

doi:10.3390/biomedicines12040915

Cited by 3 publications

(1 citation statement)

References 221 publications

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“…Ocular involvement in human immunodeficiency virus (HIV) infected and treatment-experienced patients remains a critical area of concern despite advancements in antiretroviral therapy (ART). The evolution of ART has decreased HIV-related mortality over time, but the emergence of drug resistance has created difficulties in managing these patients [ 1 ]. The prolonged life expectancy of individuals living with HIV has shifted the spectrum of HIV-associated ocular diseases.…”

Section: Introductionmentioning

confidence: 99%

Ocular involvement in highly treatment-experienced patients with HIV

2024

RJO

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Section: Introductionmentioning

confidence: 99%

Ocular involvement in highly treatment-experienced patients with HIV

2024

RJO

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An Overview of the Recent Advances in Antimicrobial Resistance

Oliveira,

Antunes,

Mota

et al. 2024

Microorganisms

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Antimicrobial resistance (AMR), frequently considered a major global public health threat, requires a comprehensive understanding of its emergence, mechanisms, advances, and implications. AMR’s epidemiological landscape is characterized by its widespread prevalence and constantly evolving patterns, with multidrug-resistant organisms (MDROs) creating new challenges every day. The most common mechanisms underlying AMR (i.e., genetic mutations, horizontal gene transfer, and selective pressure) contribute to the emergence and dissemination of new resistant strains. Therefore, mitigation strategies (e.g., antibiotic stewardship programs—ASPs—and infection prevention and control strategies—IPCs) emphasize the importance of responsible antimicrobial use and surveillance. A One Health approach (i.e., the interconnectedness of human, animal, and environmental health) highlights the necessity for interdisciplinary collaboration and holistic strategies in combating AMR. Advancements in novel therapeutics (e.g., alternative antimicrobial agents and vaccines) offer promising avenues in addressing AMR challenges. Policy interventions at the international and national levels also promote ASPs aiming to regulate antimicrobial use. Despite all of the observed progress, AMR remains a pressing concern, demanding sustained efforts to address emerging threats and promote antimicrobial sustainability. Future research must prioritize innovative approaches and address the complex socioecological dynamics underlying AMR. This manuscript is a comprehensive resource for researchers, policymakers, and healthcare professionals seeking to navigate the complex AMR landscape and develop effective strategies for its mitigation.

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Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians

Hîncu,

Apetroaei,

Ștefan

et al. 2024

Pharmaceutics

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Prevention, assessment, and identification of drug–drug interactions (DDIs) represent a challenge for healthcare professionals, especially in nosocomial settings. This narrative review aims to provide a thorough assessment of the most clinically significant DDIs for antibiotics used in healthcare-associated infections. Complex poly-pharmaceutical regimens, targeting multiple pathogens or targeting one pathogen in the presence of another comorbidity, have an increased predisposition to result in life-threatening DDIs. Recognising, assessing, and limiting DDIs in nosocomial infections offers promising opportunities for improving health outcomes. The objective of this review is to provide clinicians with practical advice to prevent or mitigate DDIs, with the aim of increasing the safety and effectiveness of therapy. DDI management is of significant importance for individualising therapy according to the patient, disease status, and associated comorbidities.

show abstract

The Phenomenon of Antiretroviral Drug Resistance in the Context of Human Immunodeficiency Virus Treatment: Dynamic and Ever Evolving Subject Matter

Cited by 3 publications

References 221 publications

Ocular involvement in highly treatment-experienced patients with HIV

Ocular involvement in highly treatment-experienced patients with HIV

An Overview of the Recent Advances in Antimicrobial Resistance

Drug–Drug Interactions in Nosocomial Infections: An Updated Review for Clinicians

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