The phenomenon of phototoxicity and long-term risks of commonly prescribed and structurally diverse drugs

Davis, Anna E.; Kennelley, Gabrielle E.; Amaye-Obu, Tatiana; Jowdy, Peter F.; Ghadersohi, Sarah; Nasir-Moin, Mehr; Paragh, Gyorgy; Berman, Harvey A.; Huss, Wendy J.

doi:10.1016/j.jpap.2023.100221

Cited by 7 publications

(2 citation statements)

References 206 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Photoallergic reactions involve an immune response triggered by exposure to sunlight, as described elsewhere (Figure 3), and are regarded as T cell-mediated delayed type hypersensitivity [5,9,13,70]. In contrast, photoirritation induces cellular cytotoxicity, is a more common affection that can happen after the first and single contact with the photosensitizer, and is dose dependent [7,9,[71][72][73].…”

Section: Discussionmentioning

confidence: 99%

Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Maddaleno,

Vinardell,

Mitjans

2024

Cosmetics

View full text Add to dashboard Cite

Photoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals. However, the prohibition of animal testing for the assessment of cosmetic ingredients in Europe and other countries underscores the necessity for in vitro or in silico alternative methods. Currently, there are no validated methods for assessing photoallergy or photosensitization, presenting a significant challenge in the development of new cosmetic ingredients. This review examines the landscape of alternative methods for detecting photosensitization, emphasizing recent publications, and considering the underlying principles of the different proposed assays.

show abstract

Section: Discussionmentioning

confidence: 99%

Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Maddaleno,

Vinardell,

Mitjans

2024

Cosmetics

View full text Add to dashboard Cite

show abstract

“…They are relatively safe and well tolerated, but at the same time, they are responsible for numerous adverse reactions, especially in elderly patients, inducing polymorphic ventricular tachycardia-torsade de pointes or tendinopathy. Also, phototoxicity is one of the frequent adverse reactions, being correlated with substitution at the X-8 position in the aromatic nucleus-Figure 1 [13][14][15]. The most common symptom of tendinopathy associated with fluoroquinolones is pain, usually of sudden onset.…”

Section: Fluoroquinolonesmentioning

confidence: 99%

Drugs Associated with Adverse Effects in Vulnerable Groups of Patients

Ștefan,

Nechita,

Dragostin

et al. 2024

Clinics and Practice

View full text Add to dashboard Cite

In recent years, a series of recommendations have been issued regarding the administration of drugs because of awareness of the serious side effects associated with certain classes of drugs, especially in vulnerable patients. Taking into account the obligation of the continuous improvement of professionals in the medical fields and the fact that we are in the midst of a “malpractice accusations pandemic”, through this work, we propose to carry out a “radiography” of the scientific literature regarding adverse effects that may occur as a result of the interaction of drugs with the physiopathological particularities of patients. The literature reports various cases regarding different classes of drugs administration associated with adverse effects in the elderly people, such as fluoroquinolones, which can cause torsade de pointes or tendinopathy, or diuretics, which can cause hypokalemia followed by torsade de pointes and cardiorespiratory arrest. Also, children are more prone to the development of adverse reactions due to their physiological particularities, while for pregnant women, some drugs can interfere with the normal development of the fetus, and for psychiatric patients, the use of neuroleptics can cause agranulocytosis. Considering the physiopathological particularities of each patient, the drug doses must be adjusted or even completely removed from the treatment scheme, thus requiring the mandatory active participation both of clinician pharmacists and specialists in the activity of medical-pharmaceutical analysis laboratories within the structure of hospitals.

show abstract

Geriatric Facial Dermatosis

Flowers,

Im,

Jowdy

et al. 2024

Curr Geri Rep

View full text Add to dashboard Cite

Purpose of Review The objective of this review is to identify and describe common facial dermatoses in the geriatric population. This review includes relevant clinical presentation, statistical data (when available), pathogenesis, differential diagnosis, associated systemic diseases, updated treatment recommendations, and recent advances in the field. Recent Findings Several medications including biological agents were recently approved by Food and Drug Administration (FDA) for treating skin diseases in general population. However, limited research data are available for the geriatric population. The choice of treatment should be guided by factors such as the specific disease type, locations of the lesions, patients’ comorbidities, and their individual preferences. Summary Recognizing and addressing facial dermatosis is becoming more crucial as the elderly population is projected to increase in the coming decades. Healthcare providers should familiarize themselves with common facial dermatoses that affect the elderly, enabling them to deliver appropriate care to enhance patients’ well-being. Managing skin dermatoses requires a comprehensive evaluation, considering the patient's comorbidities and polypharmacy, ruling out differential diagnoses, and meticulously assessing the risks and benefits of potential interventions. Future research should prioritize evaluating the effectiveness and safety of treatments specifically tailored for the geriatric population.

show abstract

The phenomenon of phototoxicity and long-term risks of commonly prescribed and structurally diverse drugs

Cited by 7 publications

References 206 publications

Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development

Drugs Associated with Adverse Effects in Vulnerable Groups of Patients

Geriatric Facial Dermatosis

Contact Info

Product

Resources

About