The phenomenon of tablet flashing — Its impact on tableting data analysis and a method to eliminate it

Paul, Shubhajit; Chang, Shao Yu; Sun, Changquan Calvin

doi:10.1016/j.powtec.2016.09.054

Cited by 33 publications

(13 citation statements)

References 19 publications

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“…Tablets were allowed to relax under ambient conditions for at least 24 h prior to being broken diametrically using a Texture Analyzer (TA-XT2i, Texture Technologies Corporation, Scarsdale, NY). Tablet flashing was carefully removed to improve the accuracy of measured tablet thickness . Tablet tensile strength was calculated from the breaking force ( F ), tablet thickness ( h ), and tablet diameter ( d ) according to eq …”

Section: Methodsmentioning

confidence: 99%

Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion

Chen

Paul

et al. 2020

Mol. Pharmaceutics

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Punch-sticking during tablet compression is a common problem for many active pharmaceutical ingredients (APIs), which renders tablet formulation development challenging. Herein, we demonstrate that the punch-sticking propensity of a highly sticky API, celecoxib (CEL), can be effectively reduced by spherical crystallization enabled by a polymer assisted quasi-emulsion solvent diffusion (QESD) process. Among three commonly used pharmaceutical polymers, poly(vinylpyrrolidone) (PVP), hydroxypropyl cellulose (HPC), and hydroxypropyl methylcellulose (HPMC), HPMC was the most effective in stabilizing the transient emulsion during QESD and retarding the coalescence of emulsion droplets and the initiation of CEL crystallization. These observations may arise from stronger intermolecular interactions between HPMC and CEL, consistent with solution 1 H NMR analyses. SEM and X-ray photoelectron spectroscopy confirmed the presence of a thin layer of HPMC on the surfaces of spherical particles. Thus, the sticking propensity was significantly reduced because the HPMC coating prevents direct contact between CEL and the punch tip during tablet compression.

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Section: Methodsmentioning

confidence: 99%

Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion

Chen

Paul

et al. 2020

Mol. Pharmaceutics

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“…Care was taken to remove the flashing before measuring tablet thickness. 10 The diametrical breaking force was then measured using a texture analyzer (TA-XT2i; Texture Technologies Corporation, Scarsdale, New York) at a speed of 0.01 mm/s. Tablet tensile strength was calculated from the maximum breaking force and tablet dimensions using eq 2(11)where σ is tensile strength (MPa), F is the breaking force (N), D is the tablet diameter (m), and T is the tablet thickness (m).…”

Section: Materials and Methodsmentioning

confidence: 99%

Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin

Li¹,

Yu²,

et al. 2019

Mol. Pharmaceutics

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As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be deposited on the surface of amorphous indomethacin by electrostatic deposition, leading to significant improvement of physical stability, wetting by aqueous media, dissolution rate, powder flow, and tabletability. The coating condition was chosen so that the positively charged polymer deposits on the negatively charged drug. Chitosan coating is superior to gelatin coating with respect to stability against crystallization and agglomeration of coated particles.

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“…The importance of the correct particle density determination for compression analysis, which significantly influences the resulting compaction parameters such as yield pressure (P Y ) within the Heckel model, has already been reported in the literature [ 18 , 21 , 23 , 25 , 39 , 40 , 41 , 42 ]. Gabaude et al [ 42 ] clearly demonstrated that errors in measuring particle density have a greater effect on P Y than the errors incurred from not correcting the displacement measurements due to punch elasticity.…”

Section: Discussionmentioning

confidence: 99%

Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on Tabletability

2022

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The present study focuses on the compaction behavior of polymeric excipients during compression in comparison to nonpolymeric excipients and its consequences on commonly used Heckel analysis. Compression analysis at compaction pressures (CPs) from 50 to 500 MPa was performed using a compaction simulator. This study demonstrates that the particle density, measured via helium pycnometer (ρpar), of polymeric excipients (Kollidon®VA64, Soluplus®, AQOAT®AS-MMP, Starch1500®, Avicel®PH101) was already exceeded at low CPs (<200 MPa), whereas the ρpar was either never reached for brittle fillers such as DI-CAFOS®A60 and tricalcium citrate or exceeded at CPs above 350 MPa (FlowLac®100, Pearlitol®100SD). We hypothesized that the threshold for exceeding ρpar is linked with predominantly elastic deformation. This was confirmed by the start of linear increase in elastic recovery in-die (ERin-die) with exceeding particle density, and in addition, by the applicability in calculating the elastic modulus via the equation of the linear increase in ERin-die. Last, the evaluation of “density under pressure” as an alternative to the ρpar for Heckel analysis showed comparable conclusions for compression behavior based on the calculated yield pressures. However, the applicability of Heckel analysis for polymeric excipients was questioned in principle. In conclusion, the knowledge of the threshold provides guidance for the selection of suitable excipients in the formulation development to mitigate the risk of tablet defects related to stored elastic energy, such as capping and lamination.

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The phenomenon of tablet flashing — Its impact on tableting data analysis and a method to eliminate it

Cited by 33 publications

References 19 publications

Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion

Reduction of Punch-Sticking Propensity of Celecoxib by Spherical Crystallization via Polymer Assisted Quasi-Emulsion Solvent Diffusion

Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin

Compression Modulus and Apparent Density of Polymeric Excipients during Compression—Impact on Tabletability

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