2024
DOI: 10.3390/ijms25169055
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The Phenomenon of Thrombotic Microangiopathy in Cancer Patients

Alexander Vorobev,
Victoria Bitsadze,
Fidan Yagubova
et al.

Abstract: Thrombotic microangiopathy (TMA) encompasses a range of disorders characterized by blood clotting in small blood vessels, leading to organ damage. It can manifest as various syndromes, including thrombotic thrombocytopenic purpura (TTP), hemolytic-uremic syndrome (HUS), and others, each with distinct causes and pathophysiology. Thrombo-inflammation plays a significant role in TMA pathogenesis: inflammatory mediators induce endothelial injury and activation of platelet and coagulation cascade, contributing to m… Show more

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