The Phenotype and Function of Lung Dendritic Cells

Webb, Tonya J.; Sumpter, Tina L.; Thiele, Allison; Swanson, Kena A.; Wilkes, David S.

doi:10.1615/critrevimmunol.v25.i6.20

Cited by 26 publications

(21 citation statements)

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“…However we have been able to show that there was a reduction in lymphocyte accumulation, a cell type shown to be pivotal for the development of allergic inflammation [35]. In contrast to our findings, a previous study has shown that melanocortin peptides did not suppress lymphocyte recruitment to the airways in female allergic balb/c mice despite, impairing eosinophil recruitment to the airways [19].…”

Section: Discussioncontrasting

confidence: 99%

A role for MC3R in modulating lung inflammation

Getting¹,

Riffo‐Vasquez²,

Pitchford³

et al. 2008

Pulmonary Pharmacology & Therapeutics

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Section: Discussioncontrasting

confidence: 99%

A role for MC3R in modulating lung inflammation

Getting¹,

Riffo‐Vasquez²,

Pitchford³

et al. 2008

Pulmonary Pharmacology & Therapeutics

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“…DCs, widely distributed throughout the conducting airways and the peripheral lung, are derived from CD34 bone marrow progenitors (35). The lower overall number could thus be a reflection of the decreased recruitment of monocytes.…”

Section: Discussionmentioning

confidence: 99%

Low Sphingosine-1–Phosphate Impairs Lung Dendritic Cells in Cystic Fibrosis

Krause

Limberis

et al. 2013

Am J Respir Cell Mol Biol

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Dysfunction of the cystic fibrosis transmembrane regulator (CFTR) leads to chronic inflammation and infection of the respiratory tract. The role of CFTR for cells of the pulmonary immune system is only partly understood. The present study analyzes the phenotype and immune stimulatory capacity of lung dendritic cells (DCs) from CFTR knockout (CF) mice. Total numbers of conventional DCs, plasmacytoid DCs, and CD103-positive DCs were lower in CF mice compared with wild-type (WT) control mice, as was the expression of major histocompatibility complex class II molecules (MHCII), CD40, and CD86. After pulmonary infection with respiratory syncytial virus, DC numbers increased in WT mice but not in CF mice, and the T cellstimulatory capacity of CF DCs was impaired. The culture of CF lung DCs with bronchoalveolar lavage fluid (BALF) from WT mice increased the expression of MHCII, CD40, and CD86. The supplementation of CF BALF with sphingosine-1-phosphate (S1P), a mediator of immune cell migration and activation that is decreased in CF BALF, rescued the reduced expression of MHCII and CD40 in WT lung DCs and human blood DCs. These findings suggest that DCs are impaired in the CF lung, and that altered S1P affects lung DC function. These findings provide a novel link between defective CFTR and pulmonary innate immune dysfunction in CF.

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“…Highly specialized and notably heterogenous, DCs function as messengers and regulators between innate and acquired immunity (e.g. Reid, 1997;Hart, 1997;Banchereau and Steinman, 1998;Austyn, 1998;Satthaporn and Eremin, 2001;Dzionek et al, 2000;Webb et al, 2005;McKenna et al, 2005;Lommatzsch et al, 2007Lommatzsch et al, , 2010GeurtsvanKessel and Lambrecht, 2008;von Garnier and Nicod, 2009). Because DCs have the ability to induce a primary immune response in resting naïve T-lymphocytes and play a role in the maintenance of B-cell function and antigen memory (recall) responses (e.g.…”

Section: Dendritic Cells (Dcs)mentioning

confidence: 99%

“…Because DCs have the ability to induce a primary immune response in resting naïve T-lymphocytes and play a role in the maintenance of B-cell function and antigen memory (recall) responses (e.g. Webb et al, 2005;Bessa et al, 2009), they were called 'professional antigen presenting cells' by, e.g., Lipscomb and Masten (2002) and Liu (2005). To better assess incoming antigens for possible threat, mature DCs particularly occur in tissues that interface between the external-and the internal environments and are therefore greatly exposed to microbial pathogens, harmful particulates, and injurious gases.…”

Section: Dendritic Cells (Dcs)mentioning

confidence: 99%

Cellular Defences of the Lung: Comparative Perspectives

Maina¹

2012

Respiratory Diseases

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'Our lungs are highly complex organs that are exquisitely specialized for gas exchange and host defense.' Rawlins (2010) 1. Introduction General considerationsThe most important function of the lung is to acquire molecular oxygen and eliminate carbon dioxide. Except probably for the gastrointestinal system, no other organ in the body interacts with the external environment as constantly and as intimately as the respiratory system. For example, during a 24 hour period, at rest, the human lung is ventilated ~25,000 times with ~20,000 L of air (e.g. Burri, 1985; Brain, 1996), it has a respiratory surface area (RSA) of ~140 m 2 (about the size of a tennis court) which is located in the acini that lie no more than 40 to 50 cm from the external environment (air) (e.g. Weibel, 1984), and the thickness of the blood-gas (tissue) barrier (BGB) (harmonic mean thickness, ht) is 0.62 μm, a value about one-fiftieth of the thickness of a foolscap paper or that of a human head hair (Gehr et al., 1978(Gehr et al., , 1990a. By weight, each day, more than 20 kg of air enters and leaves the human body, a load that far exceeds that of food and water ingested during the same time period (Brain, 1996). Depending on the level of air pollution, different types and quantities of foreign particulates and microbial pathogens are inhaled. While large RSA and thin BGB increase gas exchange, the concomitant downside to these structural properties is that they make the lung a leading portal of entry and therefore attack by pathogenic micro-organisms, damage by allergens and particulates, and injury by noxious gases (e.g. Brain, , 1992Lambrecht et al. 2001;Garn et al., 2006). The inhaled particulates are deposited on the epithelial lining of the conducting airways and that of the peripheral air spaces where they are retained for various durations before they are removed or destroyed (e.g. Geiser et al., 1988; Gehr et al., 1990 a, b). Brain (1996) observed that 'the lung is unique in that the marriage between environment and lung disease is profound. The respiratory system threfore forms a huge challenge to the body's immune integrity (e.g. von Garnier and Nicod, 2009 , 1993;Schwartz, 1994;Brunekreef et al., 1995;Ware, 2000;Pope, 2000;Nemmar et al., 2002;Pope et al., 2002;Suwa et al., 2002;Schulz et al., 2005;Kaufman, 2010;Brook et al., 2010; van den Hooven et al., 2011;Kampfrath et al., 2011 gc.ca/ccdpc-cpcmc/crdmrc/facts_gen_e.html). According to the Canadian Lung Association (CLA), the economic burden of respiratory disease in the Country is ~3 billion ($US) dollars (http://www.bukisa.com/articles/455926_lung-health-occupational-healthincidence#ixzz1I4jwMvBX). Based on net changes in gross domestic product (GDP) growth forecasts, the estimated annual cost of SARS (Sudden Avian Respiratory Syndrome) in Asia exceeds 10 billion dollars ($US) (Lee and McKibbin, 2003;Fan, 2003;McKibbin and Sidorenko, 2006) and according to the World Bank's estimates, an influenza pandemic may result in a loss (expenditure) of 800 billion dollars ($US) (Brahm...

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The Phenotype and Function of Lung Dendritic Cells

Cited by 26 publications

References 0 publications

A role for MC3R in modulating lung inflammation

A role for MC3R in modulating lung inflammation

Low Sphingosine-1–Phosphate Impairs Lung Dendritic Cells in Cystic Fibrosis

Cellular Defences of the Lung: Comparative Perspectives

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