The phenotype of peripheral blood neutrophils during the early stage of endometrial cancer

Абакумова, Т. В.; Антонеева, И. И.; Генинг, Т. П.; Долгова, Д Р; Генинг, С. О.

doi:10.1134/s1990519x16030020

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…Then, the phagocytosed material, treated with substances of the oxygen-dependent bactericidal mechanism, comes into contact with the cationic proteins of another phagocyte (Fig. 3-2) (Abakumova et al 2016). And at the final stage, the cationic proteins of the second phagocyte surround the particles phagocytosed and treated with oxidants by the first phagocyte (Fig.…”

Section: Discussionmentioning

confidence: 99%

The Cytochemical Study of Oxygen-Dependent and Oxygen-Independent Components of Bactericidal Activity of Dog' Peripheral Blood Leukocytes

2022

Int J Vet Sci

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The scientific literature does not discuss how the oxygen-dependent and oxygen-independent mechanisms of bactericidal activity of peripheral blood phagocytes relate to each other. For example, does oxygen-dependent and oxygen-independent bactericidal mechanisms act by themselves and independently? Or do they interact, potentiating each other's action? This work aimed to study the cooperation (clarification of the participation) of oxygen-dependent and oxygen-independent bactericidal systems of peripheral dog' blood neutrophils in the phagocytosis process. The mechanism of oxygen-dependent bactericidal activity of neutrophils was visualized in the NBT test. Study of the oxygen-independent bactericidal activity mechanism of neutrophils flowing through bactericidal proteins by Pigarevsky. Cytological preparations had been examining under immersion objective. Obtained results confirmed the well-known fact that a certain amount of peripheral blood granulocytes contains substances responsible for oxygendependent and bactericidal activity. These two mechanisms of bactericidal activity, responses different cells. In phagocytosis, bactericidal substances gradually accumulated around the phagocytosed material and, after a while, completely impregnated it. In addition, particles phagocytosed by leukocytes containing cationic proteins were also gradually enveloped by the latter. However, in the research process, it was not established that these proteins penetrate deeply into phagocytosed particles. In the studied preparations, several such variants of the interposition of NBTpositive phagocytes and phagocytes containing cationic proteins are visualized, suggesting that these cells can interact in phagocytosis. It was found that different granulocytic cells have oxygen-dependent and oxygen-independent bactericidal activity. Also, bactericidal activity is exposed to bactericidal action by leukocytes, responsible for the oxygen-independent activity.

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Section: Discussionmentioning

confidence: 99%

The Cytochemical Study of Oxygen-Dependent and Oxygen-Independent Components of Bactericidal Activity of Dog' Peripheral Blood Leukocytes

2022

Int J Vet Sci

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“…At the same time, according to other researchers, neutrophils isolated from the blood of patients with uterine cancer (stage Ia) had a reduced ability to form traps in response to stimulation by yeast cells [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of Combined Therapy on Generation of Neutrophil Extracellular Traps in Patients with Cervical Cancer

Fomenko¹,

Kolesnikova²,

Beynikova³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:According to several authors, neutrophil extracellular traps (NETs) play an important role in the mechanisms of cancer development and metastatic processes, which allows them to be considered as a potential new target for the treatment of cancer.AIM:To investigate the presence of extracellular neutrophil traps in the blood of patients with cervical cancer on the background of the combined treatment.MATERIALS AND METHODS:The study was conducted in 28 patients with cervical cancer. Group 1 received only radiation therapy; Groups 2-radiation therapy with ftorafur; Group 3-radiation therapy with cisplatin. To determine the number of spontaneous extracellular neutrophilic traps in the blood of the examined individuals, we used a technique of I.I. Dolgushin and Yu.S. Andreeva.RESULTS:Peripheral blood neutrophils in 53.57% (33.87; 72.49) of cervical cancer patients showed the ability to generate NETs before treatment. The ability to form NETs was observed in neutrophils isolated from 66.67% (9.43; 99.16) patients of the Group 1. After radiation therapy with ftorafur, the ability of blood neutrophils to form NETs was observed in 50% (1.26; 98.74) of cervical cancer patients. After radiotherapy with cisplatin, 37.50% (15.20; 64.57) of patients were found to have NETs formationCONCLUSION:The ability to form NETs varied greatly after radiotherapy. The addition of chemotherapy drugs to radiation therapy did not increase the percentage of NETs in the blood of patients with cervical cancer but stimulated the appearance of basophil extracellular traps.

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The Effect of Magnetite Nanoparticles and Bacteria on the Activity of NADPH-Oxidase and Myeloperoxidase in Neutrophils of Human Blood

et al. 2018

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The phenotype of peripheral blood neutrophils during the early stage of endometrial cancer

Cited by 3 publications

References 31 publications

The Cytochemical Study of Oxygen-Dependent and Oxygen-Independent Components of Bactericidal Activity of Dog' Peripheral Blood Leukocytes

The Cytochemical Study of Oxygen-Dependent and Oxygen-Independent Components of Bactericidal Activity of Dog' Peripheral Blood Leukocytes

Influence of Combined Therapy on Generation of Neutrophil Extracellular Traps in Patients with Cervical Cancer

The Effect of Magnetite Nanoparticles and Bacteria on the Activity of NADPH-Oxidase and Myeloperoxidase in Neutrophils of Human Blood

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