Molecular System Bioenergetics 2007
DOI: 10.1002/9783527621095.ch7
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The Phosphocreatine Circuit: Molecular and Cellular Physiology of Creatine Kinases, Sensitivity to Free Radicals, and Enhancement by Creatine Supplementation

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Cited by 58 publications
(67 citation statements)
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“…To further emphasize the importance of this factor, ΔG Ca 2+ transport for Ca 2+ uptake (+51 kJ mol −1 ) is only slightly less than the energy released by ATP hydrolysis (55 kJ mol −1 ) under physiological conditions, highlighting the need for a locally high ATP:ADP ratio (Wallimann and Hemmer, 1994). Fourth, tight coupling between CK and SR Ca 2+ -ATPase leads to CK-PCr-derived ATP and the dissociation of ADP from the Ca 2+ -ATPase, thereby lowering the apparent K m for ATP by the Ca 2+ -ATPase (Wallimann et al, 2007). It is unclear whether the CK protein detected here (Fig.…”
Section: Regulation Of Energy Metabolism Through the Phosphocreatine mentioning
confidence: 99%
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“…To further emphasize the importance of this factor, ΔG Ca 2+ transport for Ca 2+ uptake (+51 kJ mol −1 ) is only slightly less than the energy released by ATP hydrolysis (55 kJ mol −1 ) under physiological conditions, highlighting the need for a locally high ATP:ADP ratio (Wallimann and Hemmer, 1994). Fourth, tight coupling between CK and SR Ca 2+ -ATPase leads to CK-PCr-derived ATP and the dissociation of ADP from the Ca 2+ -ATPase, thereby lowering the apparent K m for ATP by the Ca 2+ -ATPase (Wallimann et al, 2007). It is unclear whether the CK protein detected here (Fig.…”
Section: Regulation Of Energy Metabolism Through the Phosphocreatine mentioning
confidence: 99%
“…ANTs are antiporters that exchange one ATP for one ADP. Octameric CK forms complexes with both VDACs on the outer mitochondrial membrane and with cardiolipin patches that surround the ANT (Wallimann et al, 2007). The formation of the ANT-CK-VDAC complex allows CK to convert the ATP transported by the ANT across the inner membrane into PCr, which can be transported across the outer membrane by VDAC, affecting channeling of the ATP substrate and the PCr product.…”
Section: Regulation Of Energy Metabolism Through the Phosphocreatine mentioning
confidence: 99%
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“…The role of this system in muscle, brain and other tissue with high energy requirements and fluxes has been intensively studied and debated during the last four decades. The main results and current state of art of these studies were recently summarized in a number of chapters of three almost simultaneously published books (Vial, 2006;Wallimann et al 2007;Dzeja et al 2007;Saks et al 2007;Wyss & Salomon, 2007). These studies helped to develop the new paradigm of bioenergetic studiesmolecular system bioenergetics, a part of systems biology (Saks et al 2006.…”
mentioning
confidence: 99%
“…Abundant experimental evidence shows the existence of distinct cellular ATP microdomains (compartments) localized in mitochondria and at the sites of ATP utilization. These are connected by phosphotransfer networks, notably via the PCr-creatine kinase pathway (reviewed by Wallimann et al 2007;Dzeja et al 2007;Saks et al 2007;Wyss & Salomon, 2007). These networks function to bypass and overcome local restrictions on ATP or ADP diffusion and thus perform the important tasks of both energy supply and metabolic feedback regulation of respiration (Saks et al 2006).…”
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confidence: 99%