The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery

Drescher, Simon; Hoogevest, Peter van

doi:10.3390/pharmaceutics12121235

Cited by 82 publications

(43 citation statements)

References 192 publications

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“…These phospholipids possess the same hydrophobic tail, but are different in hydrophilic heads, which may provide different microenvironments around CsPbBr 3 NCs (Figure 2a). [19,20] Thus, a series of PM-CsPbBr 3 NCs can be obtained by combining different lipid compositions (Figure 2b). In this study, DOPC was chosen as the main component, considering it has been demonstrated to be an excellent stabilizer for a variety of hydrophobic nanomaterials.…”

Section: Effect Of Membrane Compositions On Pm-cspbbr 3 Nanocrystalsmentioning

confidence: 99%

Biocatalytic CsPbX₃ Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Zeng

et al. 2021

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advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. So far, a variety of nanoscale materials, such as fullerene derivatives, [5,6] gold nanoparticles, [7,8] rare earth nanoparticles, [9] and ferromagnetic nanoparticles, [10] have been discovered to possess unique enzyme-mimic catalytic activities. These nanozymes have already found wide applications in numerous fields, including biosensing, disease therapy, detoxification, and pollutant removal. [3] Perovskite nanocrystals (NCs) have emerged as potential candidates for the next-generation lighting systems, because of their extraordinary physiochemical properties, such as, simple synthesis, high fluorescence quantum yield, narrow emission bandwidth, and wide and tunable emission covering the full visible range. [11][12][13] In consideration of their unique advantages and huge success in optoelectronics, [14,15] one may envision perovskite NCs would also hold great potential for biological applications akin to their quantum dots counterparts. However, the application of perovskite NCs in biological fields is largely lagged, because they are limited by some longstanding concerns, including extremely low stability in aqueous CsPbX 3 perovskite nanocrystals (NCs), with excellent optical properties, have drawn considerable attention in recent years. However, they also suffer from inherent vulnerability and hydrolysis, causing the new understanding or new applications to be difficultly explored. Herein, for the first time, it is discovered that the phospholipid membrane (PM)-coated CsPbX 3 NCs have intrinsic biocatalytic activity. Different from other peroxidase-like nanozymes relying on extra chromogenic reagents, the PM-CsPbX 3 NCs can be used as a self-reporting nanoprobe, allowing an "add-to-answer" detection model. Notably, the fluorescence of PM-CsPbX 3 NCs can be rapidly quenched by adding H 2 O 2 and then be restored by removing excess H 2 O 2 . Initiated from this unexpected observation, the PM-CsPbX 3 NCs can be explored to prepare multi-color bioinks and metabolite-responsive paper analytical devices, demonstrating the great potential of CsPbX 3 NCs in bioanalysis. This is the first report on the discovery of nanozyme-like property of all-inorganic CsPbX 3 perovskite NCs, which adds another piece to the nanozyme puzzle and opens new avenues for in vitro disease diagnostics.The ORCID identification number(s) for the author(s) of this article can be found under

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Section: Effect Of Membrane Compositions On Pm-cspbbr 3 Nanocrystalsmentioning

confidence: 99%

Biocatalytic CsPbX₃ Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Zeng

et al. 2021

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“…[49][50][51] Natural biomaterials are desirable in medicinal applications due to their inherent biocompatibility, biodegradability, nontoxicity, nonantigenicity, and bioadhesiveness. [52] The main biomaterials used in transdermal DDS are lipids, [53][54][55][56] hyaluronic acid, [57] and chitosan. [58] Chitosan was employed as NPs, [59,60] microneedles (MN), [61] CPEs, [62] nanofibers, [63] dermal patches and films, [64] and nanogels.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Rahamim

Azagury

2021

Adv Funct Materials

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The main purpose herein is to provide an up-to-date review on noninvasive biomimetic, bioinspired, and bioengineered drug delivery system (DDS). Noninvasive DDS is an ever-growing field critical for the applicability of drugs. It offers noninvasive administration routes with improved controlled, targeted, and triggered drug delivery. Noninvasive DDS employ many approaches and strategies, such as, nano-and microparticles, lipid-based systems, sonophoresis, electrophoresis and iontophoresis, penetration enhancers, microneedles, and gels. The last decade seen a surge in research papers employing the paradigms of biomimicry, bioinspiration, and bioengineering. However, since the use of these terms in noninvasive DDS field is often inconsistent and unclear, some generalized perspectives are provided on the possible usage of these terms in future publications. Additionally, a critical discussion on the novelty and origins of these paradigms is provided. The advantages and disadvantages of each of the noninvasive routes and their current main limitations are summarized. The main aspects of indicated fields are discussed: The unique physiology of the related tissues, the main hurdles for mass transport, the various DDS tested, and materials selection. Finally, the basic concepts and therapeutic effects of these DDS are discussed and future venues for noninvasive biomimetic, bioinspired, and bioengineered DDS research are proposed.

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“…In particular, DPPC molecules are among PC species comprising hydrophilic head groups (PC) and hydrophobic tails (palmitic acid, Fig. 2) are responsible for reducing surface tension thereby prevents alveoli collapse during the breath process [31]. Other surfactant phospholipids that exist in portions (8-15% total mass) are phosphatidylglycerol (PG) and phosphatidylinositol (PI).…”

Section: Pulmonary Surfactant Compositionmentioning

confidence: 99%

The Role of Pulmonary Surfactant in COVID-19 Understanding

Ettarhouni

Mezoughi

2021

IRJPAC

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Background: In Covid-19 the virus infects the respiratory tract in human. When lung tissue becomes diseased, the walls and lining of the alveoli and capillaries are damaged. At this point lung compliance and ventilation decrease. Pulmonary surfactant that is produced and dispersed into alveolar space, has a significant role in understanding how heavily covid-19 interferes and infects lung cells. The importance of pulmonary surfactant in alveoli is to lower surface tension at air/liquid interface in the lung. This is achieved by reducing the work of breathing and preventing alveolar collapse. The main constituent of pulmonary surfactant is dipalmitoylphosphatidylcholine (DPPC) (C40H80NO8P). It is a phospholipid containing two non polar palmitic acid C16 chains as hydrophobic tails linked to a polar head group of a phosphatidylcholine (also known as lecithin). Rationale of the Review and Objective Method: When DPPC molecules are in contact with a polar solvent, micelles which grow further into bilayers are formed considering their cylindrical structures. This trait makes the whole structure of pulmonary surfactant as amphipathic and surface active molecules. The head group of phosphatidylcholine in the pulmonary surfactant is attracted by polar liquid molecules causing a reduction of the liquid surface tension. Conclusion: This review complements the quoted information analysing them theoretically and integrates recent advances in pulmonary surfactant research with the global pandemic.

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The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery

Cited by 82 publications

References 192 publications

Biocatalytic CsPbX₃ Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Biocatalytic CsPbX₃ Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

The Role of Pulmonary Surfactant in COVID-19 Understanding

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The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery

Cited by 82 publications

References 192 publications

Biocatalytic CsPbX3 Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Biocatalytic CsPbX3 Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

The Role of Pulmonary Surfactant in COVID-19 Understanding

Contact Info

Product

Resources

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Biocatalytic CsPbX₃ Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis

Biocatalytic CsPbX₃ Perovskite Nanocrystals: A Self‐Reporting Nanoprobe for Metabolism Analysis