The photoregulation of carotenoid biosynthesis in Aspergillus giganteus mut. alba

El-Jack, Mohamed; Mackenzie, A.; Bramley, Peter M.

doi:10.1007/bf00394874

Cited by 25 publications

(6 citation statements)

References 94 publications

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“…Photo-carotenogenesis is described in numerous fungi including Fusarium spp . (Kim et al 2014a, Estrada and Avalos 2008, Ruiz-Roldan et al 2008, Avalos and Estrada 2010), Aspergillus giganteus (El-Jack et al 1988), Phycomyces blakesleeanus (Corrochano and Cerdá-Olmedo 1992, Corrochano and Garre 2010), Mucor circinelloides (Silva et al 2006), Blakeslea trispora (Quiles-Rosillo et al 2005), and even numerous freshwater yeasts, e.g. Rhodotorula (Libkind et al 2004).…”

Section: Visible Light As a Signal For Stressmentioning

confidence: 99%

Fungal photobiology: visible light as a signal for stress, space and time

2014

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Visible light is an important source of energy and information for much of life on this planet. Though fungi are neither photosynthetic nor capable of observing adjacent objects, it is estimated that the majority of fungal species display some form of light response, ranging from developmental decision making to metabolic reprogramming to pathogenesis. As such, advances in our understanding of fungal photobiology will likely reach the broad fields impacted by these organisms, including agriculture, industry and medicine. In this review, we will first describe the mechanisms by which fungi sense light and then discuss the selective advantages likely imparted by their ability to do so.

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Section: Visible Light As a Signal For Stressmentioning

confidence: 99%

Fungal photobiology: visible light as a signal for stress, space and time

2014

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“…Both isoforms showed different affinities to the cofactors Mg 2+ and Mn 2+ , which could play some role in the fine regulation of the enzyme activity. 64,89 El-Jack et al 139 reported that in non-plastidial, carotenoid biosynthesis in Aspergillus giganteus light is an important regulatory factor. Among others IPP isomerase activity was increased by light.…”

Section: Regulation Of Ipp Isomerase Activity Under Various Conditionsmentioning

confidence: 99%

Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function

Ramos-Valdivia¹,

Heijden²,

Verpoorte³

1997

Nat. Prod. Rep.

143

124

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“…A regulatory role of this enzyme has been postulated to occur in the biosynthesis of sterols in yeast (Anderson et al, 1989) and mammalian liver cells (Bruenger et al, 1986), in prenylated protein metabolism in human promyelocytes (Xuan et al, 1994), and in the biosynthesis of carotenoids in fungi and plants (El-Jack et al, 1988;Albrecht and Sandmann, 1994). In plants, it is assumed that the isomerisation takes place within three subcellular compartments : in the plastids, in the cytosol, and in the mitochondria (Gray, 1987;Kleinig, 1989).…”

mentioning

confidence: 99%

Purification and Characterization of two Isoforms of Isopentenyl‐Diphosphate Isomerase from Elicitor‐Treated Cinchona Robusta Cells

Ramos-Valdivlv¹,

Heijden²,

Verpoorte³

et al. 1997

European Journal of Biochemistry

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In Cinchona robusta (Rubiaceae) cell suspension cultures, the activity of the enzyme isopentenyldiphosphate isomerase (isopentenyl-POP isomerase) is transiently induced after addition of a homogenate of the phytopathogenic fungus Phytophthora cinnamomi. The enzyme catalyses the interconversion of isopentenyl-POP and dimethylallyl diphosphate (dimethylallyl-POP) and may be involved in the biosynthesis of anthrayuinone phytoalexins that accumulate rapidly after elicitation of Cinchona cells. From elicitor-treated C. robusta cells, two isoforms of isopentenyl-POP isomerase have been purified to apparent homogeneity in four chromatographic steps. The purified forms are monomeric enzymes of 34 kDa (isoform I) and 29 kDa (isoform 11), with K, values for isopentenyl-POP of 5.1 pM and 1.0 pM, respectively. Both isoforms require MnZ+ or Mg2+ as cofactor, isoform I1 showing a preference for Mn2+ with maximum activity at 1.5-2 mM. Isoform I was most active in the presence of 0.5-1.5 mM Mg" or in the presence of 0.5 mM MnZ+. A pH optimum of 7-7.8 was found for both forms and both were competitively inhibited by geranyl diphosphate (K, 96 pM for isoform I) and the transition state analogue 2-(dimethy1amino)ethyl diphosphate. Rechromatography of purified isoforms did not indicate any interconversion of both forms. Western blot analysis, using antibodies raised against isopentenyl-POP isomerase purified from Capsicum annuum, showed the presence of both isoforms in the crude protein extracts from C. robustu cells. Isoform I1 was specifically induced by elicitation, non-treated cells contained low activity of this isoform. The possible role of isopentenyl-POP isomerase in the biosynthesis of anthraquinones is discussed.

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The photoregulation of carotenoid biosynthesis in Aspergillus giganteus mut. alba

Cited by 25 publications

References 94 publications

Fungal photobiology: visible light as a signal for stress, space and time

Fungal photobiology: visible light as a signal for stress, space and time

Isopentenyl diphosphate isomerase: a core enzyme in isoprenoid biosynthesis. A review of its biochemistry and function

Purification and Characterization of two Isoforms of Isopentenyl‐Diphosphate Isomerase from Elicitor‐Treated Cinchona Robusta Cells

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