The photothermal effect of polypyrrole modified gold nanoparticles on SKOV-3 cells using SEM and AFM

Abstract

Nanotechnology and its application are widely used in the field of life, human exploration of life science has entered the nano level, which is of great significance for exploring the essence of cellular life. This paper explores the changes in the mechanical characteristics of tumor cells after the photothermal effect of nanomaterials. The experiments used AFM and SEM to measure and observe SKOV-3 cells before and after the treatment. It was found that the cell height, morphology, cell adhesion, and Young’s modulus had significantly changed. In the PPy-GNPs+Laser group, the adhesion force value was 3.57±1.25 nN, and Young’s modulus was 27.4±2.47 kPa. From the data, a 53.9% increase in Yong’s modulus of laser test PPy-GNPs as compared with the control group. It shows that the photothermal effect of nanoparticles has an important effect on the changes of cell ultrastructure, which has important significance for explaining the changes of cell physiological functions from the perspective of cell mechanics.