The Physical and Biological Doses of Methacholine Are Different for Mefar MB3 and Jaeger APS Sidestream Nebulizers

Praml, Georg; Scharrer, Eva; Motte, D. de la; Nowak, Dennis; Scheuch, G.; Sommerer, Knut; Radon, Katja

doi:10.1378/chest.128.5.3585

Cited by 11 publications

(17 citation statements)

References 15 publications

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“…The procedure was adapted from the European Community Respiratory Health protocol. As previously described elsewhere [23], the number of false positives at a cumulative dose of 1.2 mg was high. Therefore, a cumulative dose of 0.6 mg was chosen as a cut-off value for the analyses.…”

Section: Study Design and Data Collectionsupporting

confidence: 57%

“…The strengths of the present study were: 1) a good response to the questionnaire part of the study among a large populationbased sample of rural subjects; 2) the use of validated questionnaire instruments [23]; and 3) objective measurements of sensitisation, lung function and BHR in approximately half of the population. To reduce selection bias, subjects were a priori randomly divided in two groups.…”

Section: Discussionmentioning

confidence: 99%

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Characterisation of asthma among adults with and without childhood farm contact

Schulze

Strien²,

Praml³

et al. 2007

Eur Respir J

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Childhood farm contact is associated with a lower prevalence of sensitisation and allergic rhinitis. Findings have been contradictory for asthma. The aim of the present study was to investigate the differences between farm and nonfarm subjects using objective measurements.A cross-sectional questionnaire study was performed among rural adults aged 18-44 yrs, of which 37% lived on a farm during the first 3 yrs of life and were thus referred to as ''farm subjects''. Lung function, bronchial hyperresponsiveness (BHR) to methacholine and sensitisation were measured in a random sample. A total of 1,595 subjects were included in the analyses.Among farm subjects, sensitisation against inhalant allergens (odds ratio (OR) 0.7; 95% confidence interval 0.6-0.9), allergic rhinitis (0.5 (0.4-0.8)) and asthma diagnosis (0.7(0.4-1.1)) were less common than among nonfarm subjects. For BHR and lung function, no statistically significant differences were found between the two groups. Stratifying for sensitisation, farm subjects had a lower OR of asthma diagnosis (0.5 (0.3-1.0)) and a nonsignificantly reduced OR of BHR with sensitisation (0.8 (0.5-1.1)).The present study confirmed, using objective measurements, that farm subjects have a lower prevalence of symptoms and asthma diagnosis, while the prevalence of bronchial hyperresponsiveness does not differ.

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Section: Study Design and Data Collectionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Characterisation of asthma among adults with and without childhood farm contact

Schulze

Strien²,

Praml³

et al. 2007

Eur Respir J

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“…The MB3 nebulisers were shown by Praml [20] to have a particle size 5.4 μm mass median aerodynamic diameter (MMAD). Whereas Ryan [21] demonstrated 70% of particle size was of <5 μm MMAD for the Devilbiss 646 nebuliser.…”

Section: Discussionmentioning

confidence: 99%

Validation of the ERS standard citric acid cough challenge in healthy adult volunteers

Wright

Jackson

Thompson

et al. 2010

Cough

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Protocols measuring cough sensitivity can vary in terms of nebuliser, tussive agent, single and dose response. A definitive method for measuring cough sensitivity needs to be established. The ERS guidelines recommend the KoKo DigiDoser (KD) delivery system. Study aim, was to compare the reproducibility of this citric acid (CA) cough challenge and previously established Mefar dosimeter (MD) protocol. 39 (female 26) volunteers mean age (40.4 yrs) were randomised to either KD or MD. Intra-day and inter-day reproducibility was compared. We calculated the concentration of citric acid evoking 2 coughs (C2). The geometric mean C2 (95%CI) was similar for both KD and MD, of 263 (200,339) mM and 209 (151,288) mM respectively. The mean KD C2 was not significantly different. (F = 0.807, p = 0.93) from baseline over 1, 2, and 4 hrs however, the MD demonstrated significant variability (F = 7.85, P < 0.001) Measuring mean log C2 at baseline and at 2 weeks, the KD demonstrated a stronger intraclass correlation of log C2 at baseline with 2 week log C2, ICC = 0.70 than was shown with the Mefar, ICC = 0.41 Administering CA from KD offers a reproducible cough challenge in healthy volunteers. The results correlate well with the MD challenge but offer greater intra-day and inter-day reproducibility.

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“…Bronchial hyperresponsiveness (BHR) was tested using APS nebulizers (Viasys Health Care) according to the adapted ECRHS protocol for a stepwise methacholine challenge [29,30]. The ISAAC Phase Two protocol was not suitable for the SOLAR II age group.…”

Section: Methodsmentioning

confidence: 99%

Study on Occupational Allergy Risks (SOLAR II) in Germany: Design and methods

Heinrich¹,

Peters²,

Kellberger³

et al. 2011

BMC Public Health

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BackgroundSOLAR II is the 2nd follow-up of a population-based cohort study that follows the participants of ISAAC Phase Two recruited in Munich and Dresden in 1995/6. A first follow-up study was conducted 2002 and 2003 (SOLAR I). The aims of SOLAR II were to investigate the course of atopic diseases over puberty taking environmental and occupational risk factors into account. This paper describes the methods of the 2nd follow-up carried out from 2007 to 2009 and the challenges we faced while studying a population-based cohort of young adults.MethodsWherever possible, the same questionnaire instruments were used throughout the studies. They included questions on respiratory and allergic diseases, domestic and occupational exposure and work related stress. Furthermore, clinical examinations including skin prick tests, spirometry and bronchial challenge with methacholine, exhaled nitric oxide (FeNO) and blood samples were employed at baseline and 2nd follow-up. As information from three studies was available, multiple imputation could be used to handle missing data.ResultsOf the 3053 SOLAR I study participants who had agreed to be contacted again, about 50% had moved in the meantime and had to be traced using phone directories and the German population registries. Overall, 2904 of these participants could be contacted on average five years after the first follow-up. From this group, 2051 subjects (71%) completed the questionnaire they received via mail. Of these, 57% participated at least in some parts of the clinical examinations. Challenges faced included the high mobility of this age group. Time constraints and limited interest in the study were substantial. Analysing the results, selection bias had to be considered as questionnaire responders (54%) and those participating in the clinical part of the study (63%) were more likely to have a high parental level of education compared to non-participants (42%). Similarly, a higher prevalence of parental atopy (e.g. allergic rhinitis) at baseline was found for participants in the questionnaire part (22%) and those participating in the clinical part of the study (27%) compared to non-participants (11%).ConclusionsIn conclusion, a 12-year follow-up from childhood to adulthood is feasible resulting in a response of 32% of the baseline population. However, our experience shows that researchers need to allocate more time to the field work when studying young adults compared to other populations.

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The Physical and Biological Doses of Methacholine Are Different for Mefar MB3 and Jaeger APS Sidestream Nebulizers

Cited by 11 publications

References 15 publications

Characterisation of asthma among adults with and without childhood farm contact

Characterisation of asthma among adults with and without childhood farm contact

Validation of the ERS standard citric acid cough challenge in healthy adult volunteers

Study on Occupational Allergy Risks (SOLAR II) in Germany: Design and methods

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