The physical properties of generic latanoprost ophthalmic solutions are not identical

Kolko, Miriam; Jensen, Patricia

doi:10.1111/aos.13355

Cited by 18 publications

(15 citation statements)

References 20 publications

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“…Excipients are heterogenous inert pharmaceutical ingredients used in product formulations, for example, thickening agents and buffers. In most cases, they have limited or no pharmacological activity, but they can influence drug stability and bioavailability and these differences have the potential to affect efficacy [25,26]. Kolko and colleagues examined the physical properties of 5 generic latanoprost solutions and found substantial differences to the branded version [26].…”

Section: Tolerability and Differences In Formulationmentioning

confidence: 99%

“…Whereas the packaging of innovator products is carefully designed and evaluated in clinical trials, aiming to identify issues with bottle design, the same is not true of generic eye drops. Several studies have shown considerable variation in the force required to squeeze different bottles and successfully release a drop [26,33,34]. For example, Kolko and colleagues reported a considerable difference in force was needed to expel drops from a bottle of Xalatan compared to different generic latanoprost bottles, with Xalatan requiring the least pressure [26].…”

Section: Adherence and Ease Of Usementioning

confidence: 99%

“…Several studies have shown considerable variation in the force required to squeeze different bottles and successfully release a drop [26,33,34]. For example, Kolko and colleagues reported a considerable difference in force was needed to expel drops from a bottle of Xalatan compared to different generic latanoprost bottles, with Xalatan requiring the least pressure [26]. is is likely to be particularly important for patients who struggle to instil drops, such as those with arthritis or reduced strength.…”

Section: Adherence and Ease Of Usementioning

confidence: 99%

“…Differences in bottle design also contribute to differences in drop size and volume and number of drops per bottle, consequently affecting the quantity of active ingredient delivered to the eye [26,33,34,36]. A study by Mammo and colleagues found differences in the volume of eye drops delivered by a branded topical beta-blocker medication compared to generic versions, while others have reported similar findings with generic and branded PGAs [26,34].…”

Section: Adherence and Ease Of Usementioning

confidence: 99%

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The Use of Generic Medications for Glaucoma

Tatham

2020

Journal of Ophthalmology

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The use of generic medicines has grown considerably in recent years providing considerable cost savings. In England, generic items represented 11.7% of prescriptions for glaucoma and ocular hypertension in 2009, increasing to 55.2% of prescriptions in 2018. Generics can be brought to the market quickly and at low cost as manufacturers are not required to repeat animal or clinical research on active ingredients already approved for safety and efficacy. Although there is no regulatory requirement for studies comparing branded and generic eye drops, several randomised crossover studies have been performed comparing branded and generic prostaglandin analogues. While most have shown similar intraocular pressure lowering, studies are of short duration and have not evaluated visual field endpoints. Furthermore, differences in inactive ingredients, pH, viscosity, levels of particulate matter, and degradation over time have been reported. Other potential problems with generic eye drops include differences in bottle design affecting adherence, problems with supply, and the possibility that reduced revenue for innovator companies will lead to reduced investment in new drug development. This article reviews the potential advantages and disadvantages of generic antiglaucoma medications.

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Section: Tolerability and Differences In Formulationmentioning

confidence: 99%

Section: Adherence and Ease Of Usementioning

confidence: 99%

Section: Adherence and Ease Of Usementioning

confidence: 99%

Section: Adherence and Ease Of Usementioning

confidence: 99%

See 2 more Smart Citations

The Use of Generic Medications for Glaucoma

Tatham

2020

Journal of Ophthalmology

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“…Кроме того, изменение цвета и формы может запутать пациентов и тем самым повлиять на их приверженность лечению [19][20][21]. Исследователи из Дании M. Kolko и J. Koch [22] сравнили физические параметры оригинального препарата Ксалатан и пяти дженериков латанопроста. Полученные результаты показали значительное различие в размерах капель и количестве капель в пузырьках.…”

Section: Issues Of Safety and Efficacy Of Drugs Attracts Much Attentiunclassified

To the question about rational choice between original and generic drugs: arguments to use the first

Khodzhaev

Starostina

2019

Rossijskij oftalʹmologičeskij žurnal

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Reasons for the Underutilization of Generic Drugs by US Ophthalmologists: A Survey

et al. 2020

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Introduction: Cross-sectional survey of 92 board-certified practicing Midwestern ophthalmologists to determine why prescribing habits favor brand-name drugs over generics and to identify approaches for increasing generic drug utilization. Methods: A survey was sent to members of state ophthalmology societies, private practice groups, and individual ophthalmologists to evaluate basic demographic/practice information, knowledge and opinions on generic drugs, frequency of drug representative visits, understanding of the Food and Drug Administration's process of evaluating generics, knowledge of patients' financial status and preferences, and action items that would increase generic utilization. Results: Three factors increase the likelihood of ophthalmologists switching patients to generic drugs: increased knowledge of (1) generic options, (2) price differences between brandnames and generics, and ((3) patient preference for generics. The following four factors decrease the likelihood of ophthalmologists switching patients to generic drugs: (1) increased disease severity, (2) feeling that patient outcomes may be affected by choice of brand-name versus generic, (3) personal preference for taking a brand-name drug over a generic for their own hypothetical eye disease even if both were free, and (4) increased personal preference for taking a brand-name drug for their hypothetical eye disease. Conclusion: Ophthalmologists should continue to update themselves on generic medication options, become familiar with the price difference of generics versus brand-name drugs for commonly prescribed medications, and seek patients' opinions on generics and correct them when possible to increase generic utilization. In addition, studies evaluating the clinical equivalence of generic drugs relative to brand-name drugs should be performed and may help increase generic utilization.

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The physical properties of generic latanoprost ophthalmic solutions are not identical

Cited by 18 publications

References 20 publications

The Use of Generic Medications for Glaucoma

The Use of Generic Medications for Glaucoma

To the question about rational choice between original and generic drugs: arguments to use the first

Reasons for the Underutilization of Generic Drugs by US Ophthalmologists: A Survey

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