The Physical Properties of Poly(2-Hydroxyethyl Methacrylate) Copolymer Hydrogels Used as Intravaginal Rings

Characterization and use of ultraviolet‐reactive low‐molecular‐weight polyhydroxybutyrate to prepare biodegradable acrylates

“…The specimens pHEMA (HEMA polymer), pHEMA‐1/7 (i. e., LMWPHB/HEMA solution = 1:7), pHEMA‐1/6, pHEMA‐1/5, pHEMA‐1/4, and pHEMA‐1/3 had nominal σ T values near 12.1, 8.0, 7.5, 6.4, 4.8, and 3.6 kg/cm 2 , respectively; these values decreased significantly with increasing LMWPHB content (see Table ). The tensile properties of pHEMA have been studied widely because of the popular uses of pHEMA hydrogels; for example, it has been shown that pHEMA had σ T values near 2.6 and 1.5 kg/cm 2 when it contained different water contents of 36.2 (with the crosslinking agent ethylene glycol dimethacrylate) and 41.4 wt % (no crosslinking agent), respectively . The results here were reasonable because of the fact that the mechanical properties of pHEMA depend on the types/concentrations of monomers/crosslinkers/initiators, water/diluent contents, and curing conditions.…”

“…Consequently, although the weight loss rates or the biodegradation rates of ACRY/LMWPHB increased with the LMWPHB content, they were also much smaller than those of pHEMA/LMWPHB and changed less drastically during the testing period, especially in the first 15 days. The results indicate that the biodegradation properties of various acrylate/LMWPHB copolymers could be modified and controlled by changes in the hydrophilic properties of the acrylic constituents and could generate many diversified applications, such as artificial skin manufacturing/dressings, marrow/spinal cord cell regeneration, drug delivery, scaffolds for cell adhesion and artificial cartilage production, and bone cements, as mentioned previously . The studied materials with the combined mechanical and biodegradation properties not only could result in bioactive and biodegradable second‐generation biomaterials but could also further result in third‐generation materials capable of stimulating specific cellular responses at the molecular level for new biomedical applications …”

Development of a redox polymer based on poly(2-hydroxyethyl methacrylate) for disposable amperometric sensors

“…The literature dealing with applications of pHEMA evidences that the dimensions of the hydrogel pores can be increased by addition of a suitable amount of hydrophilic sodium methacrylate in the polymerization solution [11]. However, we could verify that too much water can enter the membranes in this case, causing loss of their physical stability.…”

Development and Characterization of Electrospun Poly(2‐hydroxy ethyl methacrylate) for Tissue Engineering Applications

“…Biodegradable polymers, such as, poly(vinyl alcohol) (PVA), 21 poly(lactide-co-glycolide) (PLGA), [22][23][24] and poly(L-lactide) (PLLA) [25][26][27][28][29][30] have been successfully electrospun for wound dressing, 31 heart tissue constructs, 14 etc. The relationship between viscosity of the solution and the M w in the preparation of electrospun p(HEMA) fiber from aqueous ethanol was investigated.…”

“…12 The controlled release of an anticancer drug doxorubicin through p(HEMA) nanoparticles 13 confirms it as an efficient drug delivery scaffold. Some authors have prepared intravaginal rings of p(HEMA) and p(HEMA) co-sodium methacrylate 14 as drug delivery devices. Moreover, few studies also show that p(HEMA) to be suitable for ophthalmic applications.…”