2024
DOI: 10.1021/acs.jpclett.4c01066
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The Physics of Antimicrobial Activity of Ionic Liquids

V. K. Sharma,
J. Gupta,
J. Bhatt Mitra
et al.

Abstract: The bactericidal potency of ionic liquids (ILs) is well-established, yet their precise mechanism of action remains elusive. Here, we show evidence that the bactericidal action of ILs primarily involves the permeabilization of the bacterial cell membrane. Our findings reveal that ILs exert their effects by directly interacting with the lipid bilayer and enhancing the membrane dynamics. Lateral lipid diffusion is accelerated, which in turn augments membrane permeability, ultimately leading to bacterial death. Fu… Show more

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