Background: This study aimed to compare the presence of blepharitis with corneal thickness, refractive values and ocular axial length changes in premenopausal and postmenopausal women. Methods: Thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol (E2), refractive values with prolactin, refractions in horizontal and vertical meridians, ocular tension (OT) values, ocular axial length, central corneal thickness and the presence of blepharitis were evaluated in 142 premenopausal patients and 153 postmenopausal patients. Results: Statistically significant differences were found for the values for right eye OT (P < 0.001), left eye OT (P < 0.001) and presence of blepharitis in the premenopausal group (p<0.001). There appears to be no relationship between the decrease in corneal refractive values and increased corneal thickness or ocular axial length. However, the presence of blepharitis and increased OT values are related.Conclusions: Woman in postmenopausal period should be examined by ophthalmologist because of significant increase in blepharitis and OT.