The physiologic basis of warm cardioplegia

Mauney, Michael C.; Krön, Irving L.

doi:10.1016/0003-4975(95)00422-h

Cited by 61 publications

(42 citation statements)

References 31 publications

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“…Although different cardioplegic techniques (crystalloid, cold and warm blood cardioplegia) have been developed to prevent this injury, 65 the protection given to the heart by cardioplegia is often inadequate, especially for surgical procedures requiring prolonged cardiac arrest. In a study carried out in patients receiving three different cold antegrade crystalloid cardioplegic solutions (St. Thomas II, Bretschneider or Hamburg, Germany), DNA fragmentation assessed by TUNEL staining in atrial biopsies was qualitatively documented in subendocardial myocytes and endothelial cells following cardioplegic arrest and reperfusion, although not in prebypass samples.…”

Section: Myocyte Apoptosis and Iatrogenic Ischemia/reperfusion Injurymentioning

confidence: 99%

Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions

Scarabelli

Gottlieb

2004

Cell Death Differ

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Ten years ago, the first finding of apoptotic cell death on the 'crime scene' of cardiac ischemia/reperfusion injury profoundly dismayed the scientific community. This observation jarred with the deeply rooted conviction that cardiac myocytes stoically 'break, but do not bend' in the fight against ischemia, instead of spontaneously accepting a peaceful demise for the greater good. Ten years later, a number of studies not only proved right the coexistence of necrosis and apoptosis on the ischemic battle field, but also implicated myocyte apoptosis in the pathogenesis of all the shapes and shades that cardiac ischemic injury can take on.

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Section: Myocyte Apoptosis and Iatrogenic Ischemia/reperfusion Injurymentioning

confidence: 99%

Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions

Scarabelli

Gottlieb

2004

Cell Death Differ

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“…Oksijen ihtiyacı, kalbin elektromekanik aktivitesinden, bazal metabolik hızından ve duvar geriliminden etkilenir. Bu nedenle korumanın temelini, genellikle potasyum ile oluşturulan elektromekanik arrest, hipotermi ile sağlanan bazal metabolik hızında azalma ve dekompresyon ile myokard duvar geriliminin azalması oluş-turur [16]. Korumanın yetersiz olması erken dönem mortalite ve morbidite ile sonuçlanır.…”

Section: Discussionunclassified

The Cardioplegia Having N-Acetylcysteine Effects on Myocardial Protection

İnce¹

2015

Ann Clin Anal Med

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“…While many studies have suggested that continuous normothermic perfusion with oxygenated potassium-enriched blood provides the ideal state for the heart during a cardiac operation, 7) the credibility of intermittent warm cardioplegic solution is not still established. To use the warm blood cardioplegia intermittently, special attention needs to be given to the interruption time of providing cardioplegia compared to cold blood cardioplegia.…”

Section: Discussionmentioning

confidence: 99%

Aortic Valve Replacement to a Patient with High Titer of Cold Agglutinin

Kansaku

Kuwaki

Amano

et al. 2012

ATCS

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A 60-year-old man was admitted to our hospital because of aortic stenosis with a peak pressure gradient of 61 mmHg, moderate aortic regurgitation, and a dilatation of the ascending aorta of 50 mm in diameter, which had grown 5 mm in 2 years. Because of severe aortic stenosis with a bicuspid valve and fast progression of the ascending aorta in size, replacements of both the aortic valve and the ascending aorta were planned. He had experienced severe acute renal failure with hemolysis because of cold agglutinin one year before the operation. The hemoglobin had decreased to 4.3 g/dL during hemolytic attack. His titer of cold agglutinin was extremely high. The titer of cold agglutinin has kept above than 1:131072 at 4 degree Celsius. It once increased to 1:524288. Both the replacement of the aortic valve and the ascending aorta under normothermic cardiopulmonary bypass using intermittent warm blood cardioplegia were completed uneventfully. He was discharged from the hospital on postoperative day 11.

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The physiologic basis of warm cardioplegia

Cited by 61 publications

References 31 publications

Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions

Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions

The Cardioplegia Having N-Acetylcysteine Effects on Myocardial Protection

Aortic Valve Replacement to a Patient with High Titer of Cold Agglutinin

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