The physiological and pathophysiological roles of the GH/IGF-axis in the kidney: Lessons from experimental rodent models

Cingel-Ristić, Vesna; Flyvbjerg, Allan; Drop, Stenvert L. S.

doi:10.1016/j.ghir.2004.06.003

Cited by 31 publications

(33 citation statements)

References 168 publications

(257 reference statements)

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“…14 Although the effects of GH deficiency and administration of GH, IGF-1 or IGFBPs have been investigated in animal studies [1][2][3]15,16 , we found no clinical study about visceral organ growth in humans with GH deficiency by a literature search.…”

Section: Discussionmentioning

confidence: 93%

Kidney growth and renal functions under the growth hormone replacement therapy in children

et al. 2014

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Objective: The aim of this study was to investigate the kidney growth and renal functions in children receiving recombinant human growth hormone (rhGH) treatment. Materials and methods: A total of 37 children who received rhGH for 1.5 years before the study was started and 48 healthy controls were included at first evaluation. Hormone levels were determined and kidney sizes were measured by ultrasound. Kidney functions were assessed by serum creatinine and estimated glomerular filtration rate (eGFR). After 3 years of first evaluation, 23 patients were re-assessed. Results: Kidney sizes were found to be lower in rhGH received children compared with controls at first evaluation (p50.05). Significant positive correlations were found between anthropometric measurements and kidney length and kidney volume (p50.05). Height was the most significant predictor of kidney volume in rhGH received children (p50.001). After 3-years of follow-up significantly increases were found in kidney length and volume compared with the first measurements (p50.05). Increase percentage of body height was similar to increasing percent of kidney length and liver long axis (14.2%, 11.7.1% and 7.7%, respectively, p40.05). Although no abnormal renal function test results were found at first and second evaluations; rhGH received children had significantly lower eGFR, at first evaluation, compared with controls; however, renal functions significantly increased after 3 years of followup (p50.05). Conclusions: In conclusion, effect rhGH treatment on kidney growth is parallel to growth in body height and other visceral organs. A 3-years rhGH treatment resulted in significant increases in renal functions.

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Section: Discussionmentioning

confidence: 93%

Kidney growth and renal functions under the growth hormone replacement therapy in children

et al. 2014

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“…Transgenic mice with global overexpression of GH and/or IGF-I have selective renal enlargement and glomerular hypertrophy, whereas only the mice with global overexpression of GH have mesangial proliferation followed by progressive glomerulosclerosis (Doi et al 1988, 1990, Mathews et al 1988, Cingel-Ristic et al 2004. Mice with global inactivation of the IGF-I gene that survive the postnatal period have reduced body weight, proportionally reduced kidney size, reduced glomerular size, and decreased number of nephrons (Rogers et al 1999, Cingel-Ristic et al 2004. However, these studies cannot evaluate the role of IGF-I in adult or aging animals, as they are confounded by affected IGF-I activity during development.…”

Section: Discussionmentioning

confidence: 99%

“…These changes could be involved in the development of the pathological glomerular changes observed in DM type I (Cingel-Ristic et al 2004, Rabkin & Schaefer 2004. Finally, GH as well as IGF-I treatment induces fluid retention due to increased renal sodium reabsorption (Feld et al 1995, Hirschberg & Adler 1998, Cingel-Ristic et al 2004, Rabkin & Schaefer 2004.…”

Section: Introductionmentioning

confidence: 99%

“…In humans with diabetes mellitus (DM) type I, circulating IGF-I is low and circulating GH levels are compensatorily high (Carroll et al 1998). At least in rodents, there is increased expression of IGF-I in the kidney of diabetic animals as well as multiple other changes in local renal growth factor levels (Cingel-Ristic et al 2004, Rabkin & Schaefer 2004. These changes could be involved in the development of the pathological glomerular changes observed in DM type I (Cingel-Ristic et al 2004, Rabkin & Schaefer 2004.…”

Section: Introductionmentioning

confidence: 99%

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Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression

Svensson¹,

Tivesten²,

Sjögren³

et al. 2007

Journal of Endocrinology

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“…Furthermore, it is important to acknowledge that bioactive IGF remained within the physiological range (26), thereby making it unlikely that this may cause unwanted long-term IGF1R-mediated side effects. Finally, it could be hypothesized that it is beneficial to suppress the augmented secretion of GH in T1D, as an elevated GH secretion has been linked to the development of late-stage diabetic complications such as retinopathy (33) and nephropathy (34).…”

Section: Discussionmentioning

confidence: 99%

Short-term effects of NPH insulin, insulin detemir, and insulin glargine on the GH–IGF1–IGFBP axis in patients with type 1 diabetes

Christiansen

Laursen

et al. 2014

European Journal of Endocrinology

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Objective: Insulin regulates the GH-IGF1 axis. Insulin analogs differ from human insulin in receptor affinity and possibly liver accessibility. Therefore, we compared the GH-IGF1 axis response with human NPH insulin, insulin detemir, and insulin glargine in patients with type 1 diabetes (T1D). Methods: A total of 17 patients (seven were women) with T1D (age of 42 (24-63) 3) mg/l!h), but in the highest AUC of bioactive IGF (3.8 (3.5-4.2) vs 3.7 (3.4-4.0) vs 4.4 (4.1-4.8) mg/l!h) (all P!0.01). These differences were unrelated to plasma glucose. By contrast, profiles of total IGF1, IGFBP2, and IGFBP3 were comparable. Conclusions: Independent of plasma glucose, a single dose of detemir caused larger suppression in serum IGFBP1 than NPH and glargine, whereas bioactive IGF was higher, thereby explaining the lower GH levels. Thus, detemir appears to be more liver specific than NPH insulin and glargine.

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The physiological and pathophysiological roles of the GH/IGF-axis in the kidney: Lessons from experimental rodent models

Cited by 31 publications

References 168 publications

Kidney growth and renal functions under the growth hormone replacement therapy in children

Kidney growth and renal functions under the growth hormone replacement therapy in children

Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression

Short-term effects of NPH insulin, insulin detemir, and insulin glargine on the GH–IGF1–IGFBP axis in patients with type 1 diabetes

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