The physiological benefits of sitting less and moving more: Opportunities for future research

Hwang, Chueh‐Lung; Chen, Szu-Hua; Chou, Chih-Hsuan; Grigoriadis, Georgios; Liao, Tzu‐Chieh; Fancher, Ibra S.; Arena, Ross; Phillips, Shane A.

doi:10.1016/j.pcad.2020.12.010

Cited by 9 publications

(5 citation statements)

References 76 publications

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“…However, multiple studies indicate that even during acute phases, the absence of physical activity is detrimental to health. [42][43][44] Prolonged periods of sedentary behaviour and bed rest may lead to complications such as disuse muscle atrophy, joint contractures, thrombotic disorders and insulin resistance, thereby delaying or impeding the recovery of patients in more active phase. 41 44 Therefore, research suggests that personalised exercise interventions should be implemented based on the individual's condition, even during severe activity periods.…”

Section: Discussionmentioning

confidence: 99%

Attitude and influencing factors on exercise in patients with moderately to severely active inflammatory bowel disease: a qualitative study

Wang,

Tong,

Niu

et al. 2023

BMJ Open

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ObjectivesTo explore the attitudes towards exercise, factors influencing exercise and exercise-related needs of patients with moderately to severely active inflammatory bowel disease.DesignA qualitative phenomenological research.SettingThe study was conducted at a comprehensive tertiary hospital in Suzhou, China, which is a secondary care facility.ParticipantsThe study included 17 participants who met specific inclusion criteria: aged between 16 and 70 years, diagnosed with inflammatory bowel disease and in a state of moderate to severe disease activity. Participants were required to be capable of clear self-expression and provide voluntary consent. Exclusion criteria included the presence of cancer or severe physical illness, cognitive impairment or mental illness.InterventionsSemistructured interviews were used to collect data.ResultsThe exercise experiences of participants with moderate to severe inflammatory bowel disease yielded three themes: attitudes towards exercise, factors influencing exercise and exercise-related needs.ConclusionThe majority of participants had negative attitudes towards exercise during periods of moderate to severe activity, largely influenced by disease activity, symptom management, inadequate knowledge of exercise and uncertainty about the value of exercise. Of particular note, professional guidance was generally recognised as stimulating a willingness to exercise positively, and participants demonstrated a strong need for professional guidance. Therefore, it is recommended that clear exercise guidelines for inflammatory bowel disease be constructed to ensure that patients receive safe and effective guidance to develop a healthy lifestyle in order to maximise the benefits of exercise.

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Section: Discussionmentioning

confidence: 99%

Attitude and influencing factors on exercise in patients with moderately to severely active inflammatory bowel disease: a qualitative study

Wang,

Tong,

Niu

et al. 2023

BMJ Open

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“…While 24 h/day prolonged bedrest leads to deconditioning of multiple systems, a response that parallels responses to microgravity during spaceflight, a less intense but an equally serious form of “deconditioning” can occur with implementation of a sedentary lifestyle where the ratio of time/day spent in physical activity declines to the point where the risk for loss of system integrity becomes more pronounced (Thijssen et al, 2011 ; Nosova et al, 2014 ; Hughson and Shoemaker, 2015 ; Canu et al, 2019 ; Eanes, 2021 ; Perez-Lasierra et al, 2021 ; Stoner et al, 2021 ; Wilson et al, 2021 ). The development of this so called “sitting disease” has evolved in populations of both adults and younger individuals spending large amounts of their day sitting due to their occupation (e.g., sitting in front of a computer or at a desk all day), watching TV, or occupied with electronic devices rather than engaging in normal physical activities such as walking where ground reaction forces require work again the forces of gravity, or engaged in various forms of exercise (e.g., aerobic or resistive) (Dunstan et al, 2021 ; Hwang et al, 2021 ; Stoner et al, 2021 ). Thus, when activity levels fall below a threshold for maintenance of system integrity, the “use it or lose it” principle appears to become activated even though the inactivity is not constant as during 24 h/day bedrest.…”

Section: Influence Of a Sedentary Lifestyle On Deconditioningmentioning

confidence: 99%

Learning From Human Responses to Deconditioning Environments: Improved Understanding of the “Use It or Lose It” Principle

Hart

2021

Front. Sports Act. Living

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Physical activity, mobility or patterned mobility (i.e., exercise) is intrinsic to the functioning of Homo sapiens, and required for maintenance of health. Thus, systems such as the musculoskeletal and cardiovascular systems appear to require constant reinforcement or conditioning to maintain integrity. Loss of conditioning or development of chronic deconditioning can have multiple consequences. The study of different types of deconditioning and their prevention or reversal can offer a number of clues to the regulation of these systems and point to how deconditioning poses risk for disease development and progression. From the study of deconditioning associated with spaceflight, a condition not predicted by evolution, prolonged bedrest, protracted sedentary behavior, as well as menopause and obesity and their consequences, provide a background to better understand human heterogeneity and how physical fitness may impact the risks for chronic conditions subsequent to the deconditioning. The effectiveness of optimized physical activity and exercise protocols likely depend on the nature of the deconditioning, the sex and genetics of the individual, whether one is addressing prevention of deconditioning-associated disease or disease-associated progression, and whether it is focused on acute or chronic deconditioning associated with different forms of deconditioning. While considerable research effort has gone into preventing deconditioning, the study of the process of deconditioning and its endpoints can provide clues to the regulation of the affected systems and their contributions to human heterogeneity that have been framed by the boundary conditions of Earth during evolution and the “use it or lose it” principle of regulation. Such information regarding heterogeneity that is elaborated by the study of deconditioning environments could enhance the effectiveness of individualized interventions to prevent deconditions or rescue those who have become deconditioned.

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“…The physiological benefits of PA in different patterns of intensity and frequency are well documented in the literature [6][7][8] . However, the consistency and magnitude of the effects of PA on cognitive functions continue to be debated and are not yet fully understood, which indicates the complexity of the neurophysiological process involved.…”

Section: Introductionmentioning

confidence: 99%

Physical activity in adults with epilepsy: clinical aspects and relationship with cognition and quality of life

Leandro-Merhi

2023

Dement. neuropsychol.

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There are several factors associated with lower participation in regular physical activity (PA) in adult patients with epilepsy (PWEs). Objective: To assess the relationship between the regular practice of PA with clinical and cognitive variables and quality of life (QoL) in PWEs. Methods: Habitual Physical Activity Questionnaire (HPAQ) was related to clinical variables, scores on the Mini-Mental State Examination (MMSE), on the Brief Cognitive Battery-Edu (BCB-Edu), on the Satisfaction Scale for Physical Activity (SSPA), and on the Quality of Life in Epilepsy Inventory (QOLIE)-31 in 60 PWEs, with a significance level of p<0.05. Results: The PWEs had a mean age of 42.4±13.6 years, 50% of whom were female. Longer length of epilepsy correlated with lower PA in leisure time (Pearson correlation [r]= -0.276; p-value [p]=0.036). The occupational physical activity scores of the HPAQ correlated positively with perception (r=0.300; p=0.021), memory (r=0.381; p=0.003), semantic verbal fluency test (SVF) (r=0.427; p=0.001), and with the total score in the MMSE (r=0.327; p=0.012). The total HPAQ score correlated with the SVF (r=0.336; p=0.009) and with the MMSE (r=0.254; p=0.049). There was no correlation among the QOLIE–31, the HPAQ, and the SSPA. Conclusions: Longer duration of epilepsy was associated with the lower practice of PA. Physical activity was associated with better performance in aspects of cognition. There was no relationship between QoL and practice and satisfaction with PA, suggesting different psychosocial aspects involved.

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The physiological benefits of sitting less and moving more: Opportunities for future research

Cited by 9 publications

References 76 publications

Attitude and influencing factors on exercise in patients with moderately to severely active inflammatory bowel disease: a qualitative study

Attitude and influencing factors on exercise in patients with moderately to severely active inflammatory bowel disease: a qualitative study

Learning From Human Responses to Deconditioning Environments: Improved Understanding of the “Use It or Lose It” Principle

Physical activity in adults with epilepsy: clinical aspects and relationship with cognition and quality of life

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